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Table 6 Comparison of the urinary hormone profile using the 4-spot (DUTCH) or 24-h urine collection method (n = 26)

From: Reliability of a dried urine test for comprehensive assessment of urine hormones and metabolites

Variable 24-h urine collection (ug/d) 4-spot (ng/mg-Cr) Z-score difference [95% CI]a ICC [95% CI]
Estrone 13.69 (6.32, 19.16) 14.37 (7.13, 18.75 0.00 [− 0.13, 0.13] 0.95 [0.89, 0.97]
Estradiol 1.73 (0.80, 3.26) 1.68 (0.92, 3.81) 0.00 [− 0.16, 0.16] 0.92 [0.83, 0.96]
Estriol 6.82 (3.57, 12.80) 7.39 (4.15, 12.96) 0.00 [− 0.24, 0.24] 0.82 [0.64, 0.91]
2-Hydroxyestrone 3.33 (1.27, 6.24) 3.72 (1.45, 6.75) − 0.00 [− 0.09, 0.09] 0.97 [0.94, 0.99]
2-Hydroxyestradiol 0.25 (0.11, 0.67) 0.30 (0.13, 0.49) − 0.00 [− 0.10, 0.10] 0.97 [0.93, 0.99]
4-Hydroxyestrone 0.37 (0.19, 0.75) 0.45 (0.27, 0.81) − 0.00 [− 0.15, 0.15] 0.93 [0.86, 0.97]
16-Hydroxyestrone 0.89 (0.42, 1.48) 0.93 (0.57, 1.69) 0.00 [− 0.19, 0.19] 0.90 [0.77, 0.95]
2-Methoxyestrone 2.27 (1.30, 3.80) 2.11 (1.54, 4.15) 0.00 [− 0.19, 0.19] 0.90 [0.78, 0.95]
Testosterone 9.15 (4.97, 51.92) 9.33 (5.36, 54.73) − 0.00 [− 0.10, 0.10] 0.97 [0.93, 0.98]
Epitestosterone 7.23 (4.01, 11.23) 7.53 (3.81, 13.90) − 0.00 [− 0.07, 0.07] 0.99 [0.97, 0.99]
5a-Dihydrotestosterone 5.53 (2.72, 11.59) 6.40 (2.16, 11.91) − 0.00 [− 0.09, 0.09] 0.97 [0.94, 0.99]
Androsterone 1331.99 (854.41, 1940.29) 1346.46 (818.59, 2065.66) − 0.00 [− 0.09, 0.09] 0.97 [0.94, 0.99]
Etiocholanolone 811.74 (463.17, 1045.23) 797.60 (475.43, 1061.66) − 0.00 [− 0.09, 0.09] 0.98 [0.95, 0.99]
5α-Androstanediol 102.50 (54.83, 197.14) 86.74 (51.31, 200.70) − 0.00 [− 0.27, 0.27] 0.78 [0.57, 0.89]
5β-Androstanediol 35.58 (14.05, 60.75) 34.49 (13.91, 62.77) 0.00 [− 0.22, 0.22] 0.85 [0.70, 0.93]
DHEA 166.14 (80.45, 431.61) 162.85 (78.17, 394.62) − 0.00 [− 0.05, 0.05] 0.99 [0.99, 1.00]
  1. The ICCs were calculated between measurements expressed as standardized sex-specific Z-scores (mean ± SD for all = 0.00 ± 0.98). Data are presented as median (IQR) for measurements and the difference (24-h minus 4-spot) in individual Z-scores is presented as mean [95% confidence interval]
  2. aAll p-values > 0.9 by paired t-test
  3. Cr: creatinine; DHEA: dehydroepiandrosterone; ICC: intraclass correlation coefficient
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