A bioanalytical UHPLC based method used for the quantification of Thymoquinone-loaded-PLGA-nanoparticles in the treatment of epilepsy

Table 5 Drug targeting efficiency and direct nose-to-brain transport following intranasal administration of different formulations

Formulations	Drug targeting efficiency (%DTE)^a	Direct nose-to-brain transport (%DTP)^a	Comparative bioavailability^a (AUC_i.n./AUC_i.v.); (%)
Formulations	Drug targeting efficiency (%DTE)^a	Direct nose-to-brain transport (%DTP)^a	Blood	Brain
THQ-S	7633.33 ± 91.78	47.01 ± 4.98	1.38 ± 0.12	6.55 ± 0.83
THQ-PLGA-NPs	8075.00 ± 113.05	89.89 ± 9.38	5.07 ± 0.67	98.24 ± 6.89

ISSN: 2661-801X