BMC Chemistry

Table 9 (a) Antibacterial activity of the synthesized derivatives (14a-l); (b) Antifungal activity of titled compounds (14a-l) Desai et al. [31]

From: Synthesis and therapeutic potential of imidazole containing compounds

(a)
Compounds	R	MIC (µg/mL) ± SD
Compounds	R	E. coli MTCC-443	P. aeruginosa MTCC-1688	S. aureus MTCC-96	S. pyogenesMTCC-442
14a	−C₆H₅	100 ± 2.03**	500 ± 2.64*	1000 ± 3.78	500 ± 2.64
14b	C₆H₅-CH₂-	500 ± 3.46*	500 ± 3.46	250 ± 3.21**	250 ± 3.04***
14c	−3-Cl-C₆H₄	50 ± 2.64***	100 ± 1.21**	200 ± 2.08*	1000 ± 4.51
14d	−4-Cl-C₆H₄	25 ± 1*	100 ± 1.51*	200 ± 2.08**	50 ± 2.64**
14e	−2,5-(Cl)₂-C₆H₃	100 ± 1	250 ± 2.51**	1000 ± 4.04	1000 ± 2.51*
14f	−4-F-C₆H₄	200 ± 1.62*	100 ± 1.60	100 ± 2.78**	1000 ± 3.78**
14 g	−3-NO₂-C₆H₄	100 ± 1**	100 ± 1.72	500 ± 3.05	250 ± 2.51***
14 h	−4-NO₂-C₆H₄	25 ± 1.62***	50 ± 1.05*	250 ± 2.16*	100 ± 1.78**
14i	−2-OH-C₆H₄	100 ± 2.15*	100 ± 1***	100 ± 2.04*	500 ± 4.50
14j	−3-OH-C₆H₄	100 ± 2.05*	50 ± 1.16**	500 ± 4.50	200 ± 2.05*
14 k	−2-OH,4-Cl-C₆H₃	200 ± 2.21*	100 ± 2.15**	250 ± 2.64**	500 ± 3.08
14 l	C₅H₄N	500 ± 3.05**	500 ± 3.78	250 ± 3.21*	100 ± 1.51*
Ampicillin		100 ± 2.05	100 ± 1.0	250 ± 1.52	100 ± 2.06

(b)
Compounds	R	MIC (µg/mL) ± SD
Compounds	R	C. albicans MTCC-227	A. niger MTCC-282	A. clavatus MTCC-1323
14a	−C₆H₅	500 ± 2.64*	500 ± 3.05*	1000 ± 3.21
14b	C₆H₅-CH₂-	1000 ± 1.04**	1000 ± 2.51**	500 ± 4.05*
14c	−3-Cl-C₆H₄	100 ± 1.51*	1000 ± 4.50	100 ± 1.64*
14d	−4-Cl-C₆H₄	200 ± 2.64*	100 ± 1.21**	500 ± 4.16
14e	−2,5-(Cl)₂-C₆H₃	100 ± 2.51**	500 ± 2.08***	500 ± 3.78**
14f	−4-F-C₆H₄	100 ± 1.78*	1000 ± 3.05	100 ± 2.78***
14 g	−3-NO₂-C₆H₄	200 ± 3.51	500 ± 4.05*	100 ± 1.51*
14 h	−4-NO₂-C₆H₄	100 ± 3.78**	100 ± 1***	200 ± 3.05**
14i	−2-OH-C₆H₄	500 ± 4.50*	250 ± 3.78**	500 ± 4.58
14j	−3-OH-C₆H₄	1000 ± 2.05***	100 ± 2.05***	500 ± 3.21**
14 k	−2-OH,4-Cl-C₆H₃	500 ± 2.08	250 ± 2.05	500 ± 3.46
14 l	C₅H₄N	200 ± 3.51**	500 ± 2.64*	100 ± 1.12*
Griseofulvin		500 ± 2.58	100 ± 1	100 ± 1.15

± SD = Standard deviation
^*Significant P < 0.05
^**Moderately significant P < 0.01
^***Extremely significant P < 0.001

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