Table 36 Antitubercular activity of synthesized compounds (84a-j) Patel et al. [53]
From: Synthesis and therapeutic potential of imidazole containing compounds
Compounds | R | Inhibition % | Activity | MIC (μg/mL) | IC50 | SI |
|---|---|---|---|---|---|---|
84a | 3-Nitro | 91 |  +  | 4.34 | 10.56 | 2.43 |
84b | 4-Bromo | 94 |  +  | 5.78 | 11.4 | 1.97 |
84c | 4-Chloro | 95 |  +  | 5.48 | 12.3 | 2.24 |
84d | 4-Fluoro | 90 |  +  | 4.86 | 8.5 | 1.74 |
84e | H | 16 | − |  > 6.25 | – | – |
84f | 4-Nitro | 98 |  +  | 3.14 | 9.8 | 3.12 |
84 g | 4-Methyl | 18 | − |  > 6.25 | – | – |
84 h | 3-Methyl | 30 | − |  > 6.25 | – | – |
84i | 2,4-Dichloro | 92 |  +  | 5.66 | 10.3 | 1.81 |
84j | 2,4-Dihydroxy | − | − |  > 6.25 | – | – |
Rifampicin |  |  |  | 0.125–0.25 |  |  > 10 |