Table 27 Antihypertensive activity of titled compounds (68a-f) in normotensive and hypertensive rats Hadizadeh et al. [46]
From: Synthesis and therapeutic potential of imidazole containing compounds
Compounds | MABP fall (SEM) in rats in doses C, in mg/kg b.w., i.v | |||||
|---|---|---|---|---|---|---|
Normotensive | Hypertensive | |||||
0.3 | 3 | 30 | 0.3 | 3 | 30 | |
68a | 26.00(2.00) | 42.00(3.00) | 47.20(3.03) | 38.40(5.37) | 46.40(2.19) | 50.00(2.00) |
68b | Nd | Nd | Nd | Nd | Nd | Nd |
68c | 22.00(2.00) | 42.00(2.00) | 57.2(2.16) | 29.60(4.56) | 54.40(7.79) | 58.00(2.73) |
68d | 18.00(2.00) | 42.00(2.00) | 47.00(1.67) | 22.40(3.58) | 48.00(1.78) | 49.20(1.78) |
68e | Nd | Nd | Nd | Nd | Nd | Nd |
68f | Nd | Nd | Nd | Nd | Nd | Nd |
69a | 17.20(2.68) | 41.60(20.60) | 53.20(2.28) | 28.00(6.20) | 52.80(11.79) | 55.20(2.28) |
69b | 26.40(5.80) | 37.20(1.55) | 38.60(3.83) | 29.00(2.9) | 45.75(8.87) | 50.80(6.60) |
69c | 23.20(7.69) | 44.80(3.34) | 56.80(3.34) | 35.20(3.35) | 56.00(4.00) | 56.80(3.34) |
69d | 27.60(1.82) | 37.40(1.15) | 36.60(3.63) | 29.00(5.10) | 42.00(7.30) | 44.5(7.60) |
69e | 15.40(0.27) | 28.60(1.09) | 33.00(1.41) | 28.00(4.70) | 36.80(1.60) | 51.00(8.70) |
69f | 17.40(1.03) | 26.60(3.19) | 36.80(5.30) | 24.80(4.56) | 42.00(5.40) | 48.00(7.40) |
Nifedipine | 27.20(2.68) | 59.60(3.84) | Nd | 42.40(5.36) | 61.20(14.46) | Nd |
DMSO | 12.00(5.65) | 12.00(3.65) | 12.00(5.65) | 14.80(6.72) | 14.80(6.72) | 14.80(6.72) |