From: Synthesis and therapeutic potential of imidazole containing compounds
Compounds | IC50 (µM) | ||||||
---|---|---|---|---|---|---|---|
HeLa | HT-29 | A549 | MCF-7 | Jurkat | RS4-11 | HL-60 | |
28a | 1260 ± 172 | 1915 ± 354 | 4733 ± 328 | 2800 ± 721 | 760 ± 136 |  > 10,000 | 2100 ± 252 |
28b | 1985 ± 126 | 1400 ± 200 | 7000 ± 1153 | 2090 ± 374 | 7569 ± 758 | 5678 ± 259 | 4800 ± 451 |
28c | 337 ± 48 | 330 ± 36 | 5600 ± 352 | 1363 ± 349.8 | 407 ± 24 | 800 ± 58 | 333 ± 41 |
28d | 51 ± 6.5 | 112 ± 15 | 121 ± 56 | 74 ± 17 | 90 ± 23 | 217 ± 46 | 29 ± 9.5 |
28e | 263 ± 39 | 647 ± 83 | 2600 ± 422 | 666 ± 231 | 365 ± 25 | 715 ± 148 | 453 ± 14 |
28f | 330 ± 25 | 377 ± 83 | 4717 ± 509 | 509 ± 25 | 136 ± 38 | 475 ± 106 | 413 ± 27 |
28 g | 623 ± 98 |  > 10,000 |  > 10,000 |  > 10,000 | 4933 ± 536 | 2567 ± 784 |  > 10,000 |
28 h | 9157 ± 1593 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 | 3466 ± 467 |
28i |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 | 3933 ± 517 |
28j |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 | 6633 ± 338 |  > 10,000 |  > 10,000 |
28 k | 3.7 ± 0.12 | 1.8 ± 0.8 | 1.9 ± 1.0 | 1.5 ± 0.2 | 1.2 ± 0.5 | 34.7 ± 0.0 | 4.8 ± 1.9 |
28 l |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |
28 m |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |  > 10,000 |
28n | 1.5 ± 0.32 | 7.5 ± 1.2 | 14 ± 2.3 | 3.4 ± 0.38 | 12 ± 6.6 | 8.6 ± 1.1 | 3.5 ± 0.73 |
28o | 3.8 ± 0.7 | 0.4 ± 0.06 | 0.57 ± 0.17 | 0.7 ± 0.06 | 0.9 ± 0.2 | 1.2 ± 0.7 | 1.8 ± 0.6 |
28p | 48 ± 2.5 | 174 ± 16 | 228 ± 81 | 69 ± 7.0 | 127 ± 27 | 85 ± 20 | 12 ± 2.5 |
28q | 2.9 ± 0.8 | 15 ± 1.3 | 63 ± 18.1 | 1.7 ± 0.6 | 42 ± 3.9 | 91 ± 8.9 | 63.0 ± 17.6 |
CA-4 | 4 ± 1 | 180 ± 30 | 3100 ± 100 | 5 ± 0.6 | 0.8 ± 0.2 | 370 ± 100 | 1 ± 0.2 |