Skip to main content

Table 17 Antitumor activity of the synthesized compounds (28a-q) Romangoli et al. [37]

From: Synthesis and therapeutic potential of imidazole containing compounds

Compounds

IC50 (µM)

HeLa

HT-29

A549

MCF-7

Jurkat

RS4-11

HL-60

28a

1260 ± 172

1915 ± 354

4733 ± 328

2800 ± 721

760 ± 136

 > 10,000

2100 ± 252

28b

1985 ± 126

1400 ± 200

7000 ± 1153

2090 ± 374

7569 ± 758

5678 ± 259

4800 ± 451

28c

337 ± 48

330 ± 36

5600 ± 352

1363 ± 349.8

407 ± 24

800 ± 58

333 ± 41

28d

51 ± 6.5

112 ± 15

121 ± 56

74 ± 17

90 ± 23

217 ± 46

29 ± 9.5

28e

263 ± 39

647 ± 83

2600 ± 422

666 ± 231

365 ± 25

715 ± 148

453 ± 14

28f

330 ± 25

377 ± 83

4717 ± 509

509 ± 25

136 ± 38

475 ± 106

413 ± 27

28 g

623 ± 98

 > 10,000

 > 10,000

 > 10,000

4933 ± 536

2567 ± 784

 > 10,000

28 h

9157 ± 1593

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

3466 ± 467

28i

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

3933 ± 517

28j

 > 10,000

 > 10,000

 > 10,000

 > 10,000

6633 ± 338

 > 10,000

 > 10,000

28 k

3.7 ± 0.12

1.8 ± 0.8

1.9 ± 1.0

1.5 ± 0.2

1.2 ± 0.5

34.7 ± 0.0

4.8 ± 1.9

28 l

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

28 m

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

 > 10,000

28n

1.5 ± 0.32

7.5 ± 1.2

14 ± 2.3

3.4 ± 0.38

12 ± 6.6

8.6 ± 1.1

3.5 ± 0.73

28o

3.8 ± 0.7

0.4 ± 0.06

0.57 ± 0.17

0.7 ± 0.06

0.9 ± 0.2

1.2 ± 0.7

1.8 ± 0.6

28p

48 ± 2.5

174 ± 16

228 ± 81

69 ± 7.0

127 ± 27

85 ± 20

12 ± 2.5

28q

2.9 ± 0.8

15 ± 1.3

63 ± 18.1

1.7 ± 0.6

42 ± 3.9

91 ± 8.9

63.0 ± 17.6

CA-4

4 ± 1

180 ± 30

3100 ± 100

5 ± 0.6

0.8 ± 0.2

370 ± 100

1 ± 0.2