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Table 3 Cytotoxicity of isolated compounds on cancerous (A549, MCF-7, MDA-MB-231) and normal (HDF) cell lines

From: Phytochemical constituents and biological activities of Salvia macrosiphon Boiss.

Compounds IC50 values (µM) and selectivity indexa (in parentheses)
A549 MCF-7 MDA-MB-231 HDF
1 19.37 ± 1.96
(17.4)
15.79 ± 0.35
(21.4)
22.24 ± 1.72
(15.2)
337.58 ± 9.20
2 170.03 ± 11.63 98.03 ± 11.27 119.51 ± 5.09 > 653
3 469.23 ± 22.75 428.05 ± 23.12 469.80 ± 23.12 > 971
4 > 100 > 100 > 100 nd
Etoposide 28.17 ± 1.32
(5.6)
37.51 ± 0.66
(4.2)
34.49 ± 0.36
(4.6)
157.50 ± 2.04
aThe selectivity index was determined as IC50 value for human normal fibroblast (HDF)/IC50 for cancerous cell line.
nd not detected