Table 3 Cytotoxicity of isolated compounds on cancerous (A549, MCF-7, MDA-MB-231) and normal (HDF) cell lines
From: Phytochemical constituents and biological activities of Salvia macrosiphon Boiss.
Compounds | IC50 values (µM) and selectivity indexa (in parentheses) | |||
|---|---|---|---|---|
A549 | MCF-7 | MDA-MB-231 | HDF | |
1 | 19.37 ± 1.96 (17.4) | 15.79 ± 0.35 (21.4) | 22.24 ± 1.72 (15.2) | 337.58 ± 9.20 |
2 | 170.03 ± 11.63 | 98.03 ± 11.27 | 119.51 ± 5.09 | > 653 |
3 | 469.23 ± 22.75 | 428.05 ± 23.12 | 469.80 ± 23.12 | > 971 |
4 | > 100 | > 100 | > 100 | nd |
Etoposide | 28.17 ± 1.32 (5.6) | 37.51 ± 0.66 (4.2) | 34.49 ± 0.36 (4.6) | 157.50 ± 2.04 |
aThe selectivity index was determined as IC50 value for human normal fibroblast (HDF)/IC50 for cancerous cell line. nd not detected | ||||