From: Design, synthesis, and biological activity of novel 1,2,4-oxadiazole derivatives
Compounds | Xoo | Xoc | ||
---|---|---|---|---|
50 µg/mL (%) | EC50 (µg/mL) | 50 µg/mL (%) | EC50 (µg/mL) | |
5a | 13.50 ± 3.33 | NT | 17.20 ± 1.60 | NT |
5b | 0 | NT | 0 | NT |
5c | 29.00 ± 3.90 | NT | 20.40 ± 1.00 | NT |
5d | 0 | NT | 0 | NT |
5e | 0 | NT | 0 | NT |
5f | 6.70 ± 4.30 | NT | 12.60 ± 1.10 | NT |
5Â g | 0 | NT | 0 | NT |
5 h | 10.10 ± 3.20 | NT | 11.30 ± 5.30 | NT |
5i | 10.90 ± 1.00 | NT | 19.40 ± 2.10 | NT |
5j | 42.17 ± 1.39 | 74.70 ± 5.46 | 41.37 ± 5.42 | 88.47 ± 4.21 |
5 k | 30.59 ± 3.19 | 85.30 ± 3.66 | 15.58 ± 2.84 | 199.65 ± 18.98 |
5 l | 14.16 ± 2.93 | 129.15 ± 11.16 | 29.95 ± 3.57 | 172.18 ± 13.94 |
5 m | 65.85 ± 3.32 | 36.25 ± 1.77 | 33.01 ± 3.23 | 76.35 ± 4.82 |
5n | 42.77 ± 2.13 | 56.75 ± 5.98 | 53.73 ± 3.24 | 50.93 ± 8.07 |
5o | 26.94 ± 0.65 | 122.80 ± 7.32 | 31.60 ± 5.28 | 108.27 ± 5.99 |
5p | 11.99 ± 1.18 | 225.35 ± 8.03 | 64.53 ± 3.42 | 31.40 ± 2.07 |
5q | 43.78 ± 2.02 | 63.32 ± 1.58 | 33.61 ± 4.13 | 123.34 ± 8.55 |
5r | 71.89 ± 1.56 | 24.14 ± 2.72 | 48.53 ± 1.66 | 51.11 ± 3.05 |
5 s | 26.30 ± 2.37 | 95.12 ± 14.87 | 30.28 ± 2.88 | 116.76 ± 13.97 |
5t | 38.16 ± 2.27 | 102.45 ± 5.99 | 50.37 ± 3.23 | 56.50 ± 6.26 |
5u | 64.97 ± 3.46 | 28.82 ± 2.25 | 65.10 ± 4.12 | 19.04 ± 2.13 |
5v | 85.37 ± 1.46 | 19.44 ± 2.22 | 64.59 ± 4.43 | 21.78 ± 2.82 |
5w | 40.60 ± 3.95 | 75.61 ± 2.21 | 40.12 ± 3.23 | 75.22 ± 3.93 |
5x | 61.97 ± 0.92 | 25.37 ± 6.98 | 40.29 ± 3.84 | 101.96 ± 5.81 |
5y | 78.44 ± 5.54 | 28.52 ± 3.14 | 20.63 ± 6.75 | 125.57 ± 15.77 |
5z | 44.07 ± 2.36 | 66.51 ± 5.53 | 53.70 ± 3.73 | 55.32 ± 2.96 |
BMT | 35.12 ± 2.72 | 77.46 ± 6.15 | 45.56 ± 5.76 | 68.50 ± 7.87 |
TDC | 25.12 ± 3.31 | 99.31 ± 7.59 | 37.58 ± 2.84 | 91.05 ± 8.84 |