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Table 7 (a) IC50 values of the synthesized novel amine derivatives. (b) CC50 values of the synthesized novel amine derivatives. (c) Selectivity index (SI) of the synthesized novel amine derivatives [50]

From: Therapeutic potential of oxadiazole or furadiazole containing compounds

Panel (a)
Compound IC50#values of 10(a-h) in (μM)
HeLa Caco-2 HepG2
10a 212.4 ± 1.2 203.6 ± 2.3 2.6 ± 0.5
10b 85.6 ± 0.8 112.5 ± 1.2 45.6 ± 1.1
10c 34.8 ± 1.3 123.8 ± 1.4 128.9 ± 3.5
10d 112.9 ± 0.4 145.6 ± 0.4 5.8 ± 1.6
10e 118.4 ± 0.5 212.3 ± 0.4 32.2 ± 0.3
10f 78.3 ± 5.4 2.3 ± 0.5 23.5 ± 4.6
10 g 56.4 ± 3.4 56.8 ± 1.2 156.7 ± 2.3
10 h 88.6 ± 1.2 34.6 ± 0.9 176.4 ± 1.6
5-FU 7.6 ± 0.3 8.8 ± 0.6 7.6 ± 0.2
Panel (b)
Compound CC50* of the compound 10(a-h) in (μM)
HeLa Caco-2 HepG2
10a 120 ± 1.2 112 ± 1.3 34 ± 0.5
10b 7.6 ± 0.6 145 ± 1.1 129 ± 0.3
10c 200 178 ± 2.3 102 ± 1.1
10d 450 100 ± 2.6 112 ± 1.4
10e 56 ± 2.4 62 ± 1.2 76 ± 3.4
10f 127 ± 3.4 87 ± 2.6 77 ± 0.4
10 g 200 23 ± 1.5 91 ± 4.3
10 h 123 ± 2.3 156 ± 0.4 73 ± 1.4
5-FU 57 ± 0.3 69 ± 2.3 52 ± 1.8
Panel (c)
Compound SI of the compound 10(a-h)
HeLa Caco-2 HepG2
10a 0.566 0.551 13.06
10b 0.887 1.288 2.828
10c 5.747 1.437 0.791
10d 3.985 0.686 19.31
10e 0.472 0.292 0.236
10f 1.621 37.8 3.276
10g 3.546 0.404 0.580
10h 1.388 4.508 0.413
5-FU 7.5 7.84 6.84
  1. *Concentration of compound at 50% of the remaining viable cells
  2. #Inhibitory concentration at 50% of the viable cells
  3.  ± Average value of the two independent experiments