|
Panel (a)
|
|---|
|
Compound
|
IC50#values of 10(a-h) in (μM)
|
|---|
|
HeLa
|
Caco-2
|
HepG2
|
|---|
|
10a
|
212.4 ± 1.2
|
203.6 ± 2.3
|
2.6 ± 0.5
|
|
10b
|
85.6 ± 0.8
|
112.5 ± 1.2
|
45.6 ± 1.1
|
|
10c
|
34.8 ± 1.3
|
123.8 ± 1.4
|
128.9 ± 3.5
|
|
10d
|
112.9 ± 0.4
|
145.6 ± 0.4
|
5.8 ± 1.6
|
|
10e
|
118.4 ± 0.5
|
212.3 ± 0.4
|
32.2 ± 0.3
|
|
10f
|
78.3 ± 5.4
|
2.3 ± 0.5
|
23.5 ± 4.6
|
|
10 g
|
56.4 ± 3.4
|
56.8 ± 1.2
|
156.7 ± 2.3
|
|
10 h
|
88.6 ± 1.2
|
34.6 ± 0.9
|
176.4 ± 1.6
|
|
5-FU
|
7.6 ± 0.3
|
8.8 ± 0.6
|
7.6 ± 0.2
|
|
Panel (b)
|
|---|
|
Compound
|
CC50* of the compound 10(a-h) in (μM)
|
|---|
|
HeLa
|
Caco-2
|
HepG2
|
|---|
|
10a
|
120 ± 1.2
|
112 ± 1.3
|
34 ± 0.5
|
|
10b
|
7.6 ± 0.6
|
145 ± 1.1
|
129 ± 0.3
|
|
10c
|
200
|
178 ± 2.3
|
102 ± 1.1
|
|
10d
|
450
|
100 ± 2.6
|
112 ± 1.4
|
|
10e
|
56 ± 2.4
|
62 ± 1.2
|
76 ± 3.4
|
|
10f
|
127 ± 3.4
|
87 ± 2.6
|
77 ± 0.4
|
|
10 g
|
200
|
23 ± 1.5
|
91 ± 4.3
|
|
10 h
|
123 ± 2.3
|
156 ± 0.4
|
73 ± 1.4
|
|
5-FU
|
57 ± 0.3
|
69 ± 2.3
|
52 ± 1.8
|
|
Panel (c)
|
|---|
|
Compound
|
SI of the compound 10(a-h)
|
|---|
|
HeLa
|
Caco-2
|
HepG2
|
|---|
|
10a
|
0.566
|
0.551
|
13.06
|
|
10b
|
0.887
|
1.288
|
2.828
|
|
10c
|
5.747
|
1.437
|
0.791
|
|
10d
|
3.985
|
0.686
|
19.31
|
|
10e
|
0.472
|
0.292
|
0.236
|
|
10f
|
1.621
|
37.8
|
3.276
|
|
10g
|
3.546
|
0.404
|
0.580
|
|
10h
|
1.388
|
4.508
|
0.413
|
|
5-FU
|
7.5
|
7.84
|
6.84
|
- *Concentration of compound at 50% of the remaining viable cells
- #Inhibitory concentration at 50% of the viable cells
- ± Average value of the two independent experiments
