Table 7 (a) IC50 values of the synthesized novel amine derivatives. (b) CC50 values of the synthesized novel amine derivatives. (c) Selectivity index (SI) of the synthesized novel amine derivatives [50]
From: Therapeutic potential of oxadiazole or furadiazole containing compounds
Panel (a) | ||||
|---|---|---|---|---|
Compound | IC50#values of 10(a-h) in (μM) | |||
HeLa | Caco-2 | HepG2 | ||
10a | 212.4 ± 1.2 | 203.6 ± 2.3 | 2.6 ± 0.5 | |
10b | 85.6 ± 0.8 | 112.5 ± 1.2 | 45.6 ± 1.1 | |
10c | 34.8 ± 1.3 | 123.8 ± 1.4 | 128.9 ± 3.5 | |
10d | 112.9 ± 0.4 | 145.6 ± 0.4 | 5.8 ± 1.6 | |
10e | 118.4 ± 0.5 | 212.3 ± 0.4 | 32.2 ± 0.3 | |
10f | 78.3 ± 5.4 | 2.3 ± 0.5 | 23.5 ± 4.6 | |
10 g | 56.4 ± 3.4 | 56.8 ± 1.2 | 156.7 ± 2.3 | |
10 h | 88.6 ± 1.2 | 34.6 ± 0.9 | 176.4 ± 1.6 | |
5-FU | 7.6 ± 0.3 | 8.8 ± 0.6 | 7.6 ± 0.2 | |
Panel (b) | ||||
|---|---|---|---|---|
Compound | CC50* of the compound 10(a-h) in (μM) | |||
HeLa | Caco-2 | HepG2 | ||
10a | 120 ± 1.2 | 112 ± 1.3 | 34 ± 0.5 | |
10b | 7.6 ± 0.6 | 145 ± 1.1 | 129 ± 0.3 | |
10c | 200 | 178 ± 2.3 | 102 ± 1.1 | |
10d | 450 | 100 ± 2.6 | 112 ± 1.4 | |
10e | 56 ± 2.4 | 62 ± 1.2 | 76 ± 3.4 | |
10f | 127 ± 3.4 | 87 ± 2.6 | 77 ± 0.4 | |
10 g | 200 | 23 ± 1.5 | 91 ± 4.3 | |
10 h | 123 ± 2.3 | 156 ± 0.4 | 73 ± 1.4 | |
5-FU | 57 ± 0.3 | 69 ± 2.3 | 52 ± 1.8 | |
Panel (c) | ||||
|---|---|---|---|---|
Compound | SI of the compound 10(a-h) | |||
HeLa | Caco-2 | HepG2 | ||
10a | 0.566 | 0.551 | 13.06 | |
10b | 0.887 | 1.288 | 2.828 | |
10c | 5.747 | 1.437 | 0.791 | |
10d | 3.985 | 0.686 | 19.31 | |
10e | 0.472 | 0.292 | 0.236 | |
10f | 1.621 | 37.8 | 3.276 | |
10g | 3.546 | 0.404 | 0.580 | |
10h | 1.388 | 4.508 | 0.413 | |
5-FU | 7.5 | 7.84 | 6.84 | |