Table 5 Minimum inhibitory concentration (MIC) of titled compounds [49]
From: Therapeutic potential of oxadiazole or furadiazole containing compounds
Compound | Â | S. aureus | B. subtilis | P. aeruginosa | E. coli | C. albicans | |
|---|---|---|---|---|---|---|---|
R | X | ATCC 25923 | ATCC 6633 | ATCC 27853 | ATCC 27853 | ATCC 10231 | |
6a | C6H5 | O | 0.3 | 0.15 | 0.15 | 1.25 | 2.5 |
6b | 2-CH3 C6H5 | O | 0.31 | 0.07 | 1.25 | 0.625 | 5.0 |
6c | 3-CH3 C6H5 | O | 0.625 | 0.15 | 5.0 | 2.5 | 10 |
6d | 4-CH3 C6H5 | O | 2.5 | 2.5 | 0.03 | 5.0 | 1.25 |
6e | 2-Cl C6H5 | O | 0.15 | 1.25 | 0.019 | 0.019 | 5.0 |
6f | 3-Cl C6H5 | O | 0.15 | 0.625 | 1.25 | 1.25 | 2.5 |
6g | 4-Cl C6H5 | O | 0.15 | 0.3 | 0.019 | 0.07 | 0.15 |
6h | 3-NO2 C6H5 | O | - | 10 | 1.25 | – | – |
6i | 4-NO2 C6H5 | O | 2.5 | – | 0.625 | 5.0 | 10 |
7a | 2-CH3 C6H5 | S | 1.25 | – | 2.5 | 10 | – |
7b | 4-CH3 C6H5 | S | 1.25 | 5.0 | 2.5 | 1.25 | 5.0 |
7c | 3-OH C6H5 | S | 2.5 | 1.25 | 0.019 | 2.5 | 10 |
7d | 4-OH C6H5 | S | 0.15 | 0.625 | 2.5 | 0.625 | 1.25 |
7e | 4-Cl C6H5 | S | 0.625 | 0.07 | 5.0 | 0.03 | 0.31 |
7f | 3-NO2 C6H5 | S | 2.5 | 2.5 | 10 | 1.25 | 2.5 |
7g | 4-NO2 C6H5 | S | 2.5 | 5.0 | 5.0 | 0.1 | 0.15 |
Ampicillin |  |  | 0.019 | 0.005 | 0.005 | 0.01 | – |
Fluconazole |  |  | – | – | – | – | 0.01 |