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Table 24 (a) DPPH assay of synthesized compounds. (b) Nitric oxide scavenging of synthesized compounds. (c) Hydrogen peroxide scavenging of synthesized compounds

From: Therapeutic potential of oxadiazole or furadiazole containing compounds

Compound % Scavenging activity at different concentrations IC50
20 (µg/ml) 40 (µg/ml) 60 (µg/ml) 80 (µg/ml) 100 (µg/ml)
Panel (a)
54a 39.94 ± 0.521 59.14 ± 0.652 61.38 ± 0.631 63.59 ± 0.245 65.34 ± 0.534 29.7
54b 46.63 ± 0.342 49.7 ± 0.352 57.51 ± 0.421 60.51 ± 0.634 62.65 ± 0.453 43.3
54c 44.86 ± 0.245 62.22 ± 0.214 64.66 ± 0.341 65.82 ± 0.372 67.76 ± 0.215 26.7
54d 44.64 ± 0.234 53.89 ± 0.123 62.73 ± 0.223 64.02 ± 0.321 66.92 ± 0.431 27.1
54e 47.34 ± 0.235 48.16 ± 0.516 49.54 ± 0.461 52.98 ± 0.371 55.75 ± 0.297 61.3
Ascorbic acid 49.38 ± 0.515 67.03 ± 0.541 75.78 ± 0.223 91.92 ± 0.561 95.34 ± 0.111 21.3
Panel (b)
54a 34.83 ± 0.527 40.63 ± 0.654 43.87 ± 0.691 52.15 ± 0.215 53.11 ± 0.514 72.1
54b 27.34 ± 0.372 29.81 ± 0.352 38.25 ± 0.421 42.55 ± 0.639 50.54 ± 0.450 98.3
54c 33.57 ± 0.243 44.97 ± 0.211 48.69 ± 0.348 52.35 ± 0.442 53.15 ± 0.218 66.2
54d 33.28 ± 0.232 44.40 ± 0.128 45.70 ± 0.224 52.01 ± 0.331 54.29 ± 0.481 69.8
54e 26.67 ± 0.295 29.30 ± 0.506 44.95 ± 0.411 51.98 ± 0.381 52.07 ± 0.297 70.6
Ascorbic acid 47.53 ± 0.624 63.44 ± 0.521 84.28 ± 0.623 90.53 ± 0.411 93.56 ± 0.221 25.2
Panel (c)
54a 35.75 ± 0.612 44.97 ± 0.237 55.19 ± 0.226 65.93 ± 0.662 67.14 ± 0.653 47.1
54b 34.01 ± 0.563 43.51 ± 0.464 58.83 ± 0.152 60.48 ± 0.353 62.50 ± 0.452 49.1
54c 34.24 ± 0.263 46.06 ± 0.533 58.82 ± 0.623 62.12 ± 0.621 63.63 ± 0.236 43.3
54d 33.93 ± 0.235 46.81 ± 0.516 56.52 ± 0.532 59.89 ± 0.623 61.39 ± 0.425 45.6
54e 34.48 ± 0.342 44.88 ± 0.345 55.57 ± 0.173 56.61 ± 0.535 58.63 ± 0.654 50.6
Ascorbic acid 44.53 ± 0.526 64.65 ± 0.653 71.74 ± 0.36 89.22 ± 0.621 96.19 ± 0.456 26.9
  1. IC50 values in µg/ml for samples were determined using ED50 plus V 1.0 software. Data are the mean of three or more experiments and reported as mean ± standard error of the mean (SEM)