Table 24 (a) DPPH assay of synthesized compounds. (b) Nitric oxide scavenging of synthesized compounds. (c) Hydrogen peroxide scavenging of synthesized compounds
From: Therapeutic potential of oxadiazole or furadiazole containing compounds
Compound | % Scavenging activity at different concentrations | IC50 | ||||
|---|---|---|---|---|---|---|
20 (µg/ml) | 40 (µg/ml) | 60 (µg/ml) | 80 (µg/ml) | 100 (µg/ml) | ||
Panel (a) | ||||||
54a | 39.94 ± 0.521 | 59.14 ± 0.652 | 61.38 ± 0.631 | 63.59 ± 0.245 | 65.34 ± 0.534 | 29.7 |
54b | 46.63 ± 0.342 | 49.7 ± 0.352 | 57.51 ± 0.421 | 60.51 ± 0.634 | 62.65 ± 0.453 | 43.3 |
54c | 44.86 ± 0.245 | 62.22 ± 0.214 | 64.66 ± 0.341 | 65.82 ± 0.372 | 67.76 ± 0.215 | 26.7 |
54d | 44.64 ± 0.234 | 53.89 ± 0.123 | 62.73 ± 0.223 | 64.02 ± 0.321 | 66.92 ± 0.431 | 27.1 |
54e | 47.34 ± 0.235 | 48.16 ± 0.516 | 49.54 ± 0.461 | 52.98 ± 0.371 | 55.75 ± 0.297 | 61.3 |
Ascorbic acid | 49.38 ± 0.515 | 67.03 ± 0.541 | 75.78 ± 0.223 | 91.92 ± 0.561 | 95.34 ± 0.111 | 21.3 |
Panel (b) | ||||||
54a | 34.83 ± 0.527 | 40.63 ± 0.654 | 43.87 ± 0.691 | 52.15 ± 0.215 | 53.11 ± 0.514 | 72.1 |
54b | 27.34 ± 0.372 | 29.81 ± 0.352 | 38.25 ± 0.421 | 42.55 ± 0.639 | 50.54 ± 0.450 | 98.3 |
54c | 33.57 ± 0.243 | 44.97 ± 0.211 | 48.69 ± 0.348 | 52.35 ± 0.442 | 53.15 ± 0.218 | 66.2 |
54d | 33.28 ± 0.232 | 44.40 ± 0.128 | 45.70 ± 0.224 | 52.01 ± 0.331 | 54.29 ± 0.481 | 69.8 |
54e | 26.67 ± 0.295 | 29.30 ± 0.506 | 44.95 ± 0.411 | 51.98 ± 0.381 | 52.07 ± 0.297 | 70.6 |
Ascorbic acid | 47.53 ± 0.624 | 63.44 ± 0.521 | 84.28 ± 0.623 | 90.53 ± 0.411 | 93.56 ± 0.221 | 25.2 |
Panel (c) | ||||||
54a | 35.75 ± 0.612 | 44.97 ± 0.237 | 55.19 ± 0.226 | 65.93 ± 0.662 | 67.14 ± 0.653 | 47.1 |
54b | 34.01 ± 0.563 | 43.51 ± 0.464 | 58.83 ± 0.152 | 60.48 ± 0.353 | 62.50 ± 0.452 | 49.1 |
54c | 34.24 ± 0.263 | 46.06 ± 0.533 | 58.82 ± 0.623 | 62.12 ± 0.621 | 63.63 ± 0.236 | 43.3 |
54d | 33.93 ± 0.235 | 46.81 ± 0.516 | 56.52 ± 0.532 | 59.89 ± 0.623 | 61.39 ± 0.425 | 45.6 |
54e | 34.48 ± 0.342 | 44.88 ± 0.345 | 55.57 ± 0.173 | 56.61 ± 0.535 | 58.63 ± 0.654 | 50.6 |
Ascorbic acid | 44.53 ± 0.526 | 64.65 ± 0.653 | 71.74 ± 0.36 | 89.22 ± 0.621 | 96.19 ± 0.456 | 26.9 |