|
Panel (a)
|
|---|
|
Compound
|
HIV I (μg/ml)
|
SI
|
HIV II (μg/ml))
|
SI
|
|---|
|
IC50
|
CC50
|
IC50
|
CC50
|
|---|
|
35a
|
> 50
|
= 50
|
< 1
|
> 57
|
= 57
|
< 1
|
|
35b
|
> 65
|
= 65
|
< 1
|
> 60
|
= 60
|
< 1
|
|
35c
|
> 125
|
> 125
|
X1
|
> 125
|
> 125
|
X1
|
|
35f
|
> 125
|
> 125
|
X1
|
> 38
|
> 125
|
> 3
|
|
35 g
|
> 125
|
> 125
|
X1
|
> 125
|
> 125
|
X1
|
|
35 h
|
> 125
|
> 125
|
X1
|
> 125
|
> 125
|
X1
|
|
35i
|
> 125
|
> 125
|
X1
|
> 125
|
> 125
|
X1
|
|
35j
|
> 125
|
> 125
|
X1
|
> 125
|
> 125
|
X1
|
|
Nevirapine(μM)
|
> 0.25
|
> 200
|
> 800
|
–
|
–
|
–
|
|
DDI (μM)
|
> 5.37
|
> 529
|
> 98
|
2.71
|
> 529
|
> 195
|
|
Panel (b)
|
|---|
|
Compound
|
Minimum cytotocic concentrationa (μg/mL)
|
EC50b (μg/mL)
|
|---|
|
Para-influenza-3 virus
|
Retrovirus
|
Sindbis virus
|
Coxasacide B4 virus
|
Punta Toro virus
|
|---|
|
35a
|
20
|
> 20
|
> 20
|
> 20
|
> 20
|
> 20
|
|
35b
|
100
|
> 20
|
> 20
|
> 20
|
> 20
|
> 20
|
|
35c
|
100
|
> 20
|
> 20
|
> 20
|
> 20
|
> 20
|
|
35f
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35 g
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35 h
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35i
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35j
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
Ribavirin (μM)
|
> 250
|
146
|
250
|
> 250
|
> 250
|
146
|
|
Panel (c)
|
|---|
|
Compound
|
Minimum cytotocic concentrationa (μg/mL)
|
EC50b (μg/mL)
|
|---|
|
Herpes simplex virus-1
|
Herpes simplex virus-2
|
Vaccinia virus
|
Vesicular stomatitis virus
|
|---|
|
35a
|
> 100
|
50
|
100
|
45
|
> 100
|
|
35b
|
100
|
> 20
|
> 20
|
> 20
|
> 20
|
|
35c
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35f
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35g
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35h
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35i
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
35j
|
> 100
|
> 100
|
> 100
|
> 100
|
> 100
|
|
Brivudin (μM)
|
> 250
|
0.04
|
50
|
2
|
250
|
|
Cidofovir (μM)
|
> 250
|
1
|
1
|
2
|
> 250
|
|
Ganciclovir (μM)
|
> 100
|
0.02
|
0.07
|
> 100
|
> 100
|
- aConcentration required to cause a microscopically detectable alteration of normal cell morphology, bConcentration required to reduce virus-induced cytopathogenicity by 50%
