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Table 19 (a) Anti HIV activity of synthesized compounds. (b) Cytotoxicity and antiviral activity of titled compounds in Vero cell cultures. (c) Cytotoxicity and antiviral activity of titled compounds in HEL cell cultures [47]

From: Therapeutic potential of oxadiazole or furadiazole containing compounds

Panel (a)

Compound

HIV I (μg/ml)

SI

HIV II (μg/ml))

SI

IC50

CC50

IC50

CC50

35a

 > 50

 = 50

 < 1

 > 57

 = 57

 < 1

35b

 > 65

 = 65

 < 1

 > 60

 = 60

 < 1

35c

 > 125

 > 125

X1

 > 125

 > 125

X1

35f

 > 125

 > 125

X1

 > 38

 > 125

 > 3

35 g

 > 125

 > 125

X1

 > 125

 > 125

X1

35 h

 > 125

 > 125

X1

 > 125

 > 125

X1

35i

 > 125

 > 125

X1

 > 125

 > 125

X1

35j

 > 125

 > 125

X1

 > 125

 > 125

X1

Nevirapine(μM)

 > 0.25

 > 200

 > 800

DDI (μM)

 > 5.37

 > 529

 > 98

2.71

 > 529

 > 195

Panel (b)

Compound

Minimum cytotocic concentrationa (μg/mL)

EC50b (μg/mL)

Para-influenza-3 virus

Retrovirus

Sindbis virus

Coxasacide B4 virus

Punta Toro virus

35a

20

 > 20

 > 20

 > 20

 > 20

 > 20

35b

100

 > 20

 > 20

 > 20

 > 20

 > 20

35c

100

 > 20

 > 20

 > 20

 > 20

 > 20

35f

 > 100

 > 100

 > 100

 > 100

 > 100

 > 100

35 g

 > 100

 > 100

 > 100

 > 100

 > 100

 > 100

35 h

 > 100

 > 100

 > 100

 > 100

 > 100

 > 100

35i

 > 100

 > 100

 > 100

 > 100

 > 100

 > 100

35j

 > 100

 > 100

 > 100

 > 100

 > 100

 > 100

Ribavirin (μM)

 > 250

146

250

 > 250

 > 250

146

Panel (c)

Compound

Minimum cytotocic concentrationa (μg/mL)

EC50b (μg/mL)

Herpes simplex virus-1

Herpes simplex virus-2

Vaccinia virus

Vesicular stomatitis virus

35a

 > 100

50

100

45

 > 100

35b

100

 > 20

 > 20

 > 20

 > 20

35c

 > 100

 > 100

 > 100

 > 100

 > 100

35f

 > 100

 > 100

 > 100

 > 100

 > 100

35g

 > 100

 > 100

 > 100

 > 100

 > 100

35h

 > 100

 > 100

 > 100

 > 100

 > 100

35i

 > 100

 > 100

 > 100

 > 100

 > 100

35j

 > 100

 > 100

 > 100

 > 100

 > 100

Brivudin (μM)

 > 250

0.04

50

2

250

Cidofovir (μM)

 > 250

1

1

2

 > 250

Ganciclovir (μM)

 > 100

0.02

0.07

 > 100

 > 100

  1. aConcentration required to cause a microscopically detectable alteration of normal cell morphology, bConcentration required to reduce virus-induced cytopathogenicity by 50%