Table 16 Antitubercular activity of the synthesized compounds (29a-l) against M. tuberculosis H37Rv [57]
From: Therapeutic potential of oxadiazole or furadiazole containing compounds
| Compound | Primary screen (6.25 μg/ml) | % inhibition | Concentration (μM) | Actual MIC (μg/Ml) | Clog P̽ |
|---|---|---|---|---|---|
| 29a | > 6.25 | 64 | 0.0354 | – | 0.4996 |
| 29b | > 6.25 | 12 | 0.1640 | – | 1.5150 |
| 29c | > 6.25 | 32 | 0.1706 | – | 1.5150 |
| 29d | > 6.25 | 28 | 0.1735 | – | 1.5150 |
| 29e | > 6.25 | 92 | 0.0077 | 6.05 | 0.8964 |
| 29f | > 6.25 | 86 | 0.00132 | 5.92 | 0.8964 |
| 29g | > 6.25 | 96 | 0.0052 | 6.00 | 0.8964 |
| 29h | > 6.25 | 63 | 0.1130 | – | 0.9986 |
| 29i | 6.25 | 62 | 0.1138 | – | 0.9986 |
| 29j | > 6.25 | 64 | 0.1133 | – | 0.9986 |
| 29k | > 6.25 | 96 | 0.0089 | 5.77 | − 0.8943 |
| 29l | 6.25 | 69 | 0.1184 | – | − 9.1673 |
| Isoniazid | > 6.25 | 98 | 0.025 | 0.05 | − 0.6680 |