Table 16 Antitubercular activity of the synthesized compounds (29a-l) against M. tuberculosis H37Rv [57]
From: Therapeutic potential of oxadiazole or furadiazole containing compounds
Compound | Primary screen (6.25 μg/ml) | % inhibition | Concentration (μM) | Actual MIC (μg/Ml) | Clog P̽ |
|---|---|---|---|---|---|
29a |  > 6.25 | 64 | 0.0354 | – | 0.4996 |
29b |  > 6.25 | 12 | 0.1640 | – | 1.5150 |
29c |  > 6.25 | 32 | 0.1706 | – | 1.5150 |
29d |  > 6.25 | 28 | 0.1735 | – | 1.5150 |
29e |  > 6.25 | 92 | 0.0077 | 6.05 | 0.8964 |
29f |  > 6.25 | 86 | 0.00132 | 5.92 | 0.8964 |
29g |  > 6.25 | 96 | 0.0052 | 6.00 | 0.8964 |
29h |  > 6.25 | 63 | 0.1130 | – | 0.9986 |
29i | 6.25 | 62 | 0.1138 | – | 0.9986 |
29j |  > 6.25 | 64 | 0.1133 | – | 0.9986 |
29k |  > 6.25 | 96 | 0.0089 | 5.77 | − 0.8943 |
29l | 6.25 | 69 | 0.1184 | – | − 9.1673 |
Isoniazid |  > 6.25 | 98 | 0.025 | 0.05 | − 0.6680 |