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Table 16 Antitubercular activity of the synthesized compounds (29a-l) against M. tuberculosis H37Rv [57]

From: Therapeutic potential of oxadiazole or furadiazole containing compounds

Compound Primary screen (6.25 μg/ml) % inhibition Concentration (μM) Actual MIC (μg/Ml) Clog P̽
29a  > 6.25 64 0.0354 0.4996
29b  > 6.25 12 0.1640 1.5150
29c  > 6.25 32 0.1706 1.5150
29d  > 6.25 28 0.1735 1.5150
29e  > 6.25 92 0.0077 6.05 0.8964
29f  > 6.25 86 0.00132 5.92 0.8964
29g  > 6.25 96 0.0052 6.00 0.8964
29h  > 6.25 63 0.1130 0.9986
29i 6.25 62 0.1138 0.9986
29j  > 6.25 64 0.1133 0.9986
29k  > 6.25 96 0.0089 5.77 − 0.8943
29l 6.25 69 0.1184 − 9.1673
Isoniazid  > 6.25 98 0.025 0.05 − 0.6680