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Table 14 MIC100 values of 23a-e against virulent, non-virulent and RIF-resistant M. tuberculosis bacteria [44]

From: Therapeutic potential of oxadiazole or furadiazole containing compounds

Compound R MIC100 (μg/ml) in H37Rv ATCC 27294 MIC100 (μg/ml) inH37Ra MIC100 (μg/ml) in Mtb-209 (resistant)
23a 5-NO2C4H2O 7.80 1–2.00 7.8
23b 5-NO2C4H2S 15.60 15.60 15.60
23c 5-NO2C4H3O 31.25 7.8 7.8
23d 5-NO2C6H4 15.60 31.30 15.60
23e 5-C6H5 15.60 62.50 31.25
Rifampin - 0.06 0.008  > 64
  1. M. tuberculosis H37Rv ATCC 27294 reference strain; Mtb. M. tuberculosis H37Ra non-virulent strain; Mtb-209 RIF-resistant clinical isolate of M. tuberculosis