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Table 11 Anticancer activity of synthesized compounds against HeLa, IMR-32 & MCF-7 cancer cells using MTT assay [53]

From: Therapeutic potential of oxadiazole or furadiazole containing compounds

Compound R1 R2 IC50 (μM)*(HeLa) IC50 (μM)*(IMR-32) IC50 (μM)* (MCF-7)
Isatin    521.9 352.74 410.95
17 Intermediate   309.59 176.85 206.95
17a H H 25.47 30.65 33.62
17b F H 11.99 13.48 15.57
17c Cl H 12.84 15.84 16.68
17d Br H 10.64 12.68 16.06
17e CH3 H 22.59 27.25 29.38
17f NO2 H 18.60 22.51 24.48
17 g COOH H 17.25 20.85 22.95
17 h H Cl 18.69 22.51 24.92
17i H NO2 16.20 19.35 20.38
17j H CH3 15.12 18.32 20.95
17 k H COOH 20.36 24.28 25.98
17 l H COOCH3 19.32 23.85 25.18
Cisplatin    14.08 13.64 13.54
  1. Values are expressed as means (n = 4)