Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents

BMC Chemistry

Table 1 Physicochemical characterization of synthesized derivatives (T₁–T₂₀)

Comp	Mol. formula	Mol. wt	Colour	M.p. (°C)	Rf value	% Yield
Int-ii	C₁₈H₃₆O	284.84	White	121–124	0.37^a	71.0
Int-iii	C₁₇H₃₁N₂OS	312.51	Yellow	154–157	0.42^a	52.1
Int-iv	C₁₇H₃₄N₄S	326.54	Pinkish white	178–181	0.41^b	46.0
T₁	C₂₄H₃₈N₄S	414.65	Creamish white	184–187	0.40^b	78.0
T₂	C₂₅H₃₈N₄OS	442.66	Light brown	182–185	0.33^b	82.0
T₃	C₂₅H₄₀N₄S	428.68	Yellowish white	190–193	0.52^b	74.0
T₄	C₂₆H₄₃N₄O₂S	474.70	White	188–191	0.60^b	85.0
T₅	C₂₇H₄₄N₄O₃S	504.73	Yellow	187–190	0.38^b	79.5
T₆	C₂₅H₄₀N₄O₂S	460.68	Creamish white	189–192	0.49^b	84.6
T₇	C₂₄H₃₈N₄OS	430.65	Lemon yellow	181–184	0.32^b	78.0
T₈	C₂₄H₃₈N₄OS	430.65	Greenish white	192–195	0.73^b	65.9
T₉	C₂₆H₄₃N₅S	457.72	Green	198–201	0.62^b	75.0
T₁₀	C₂₄H₃₇ClN₄S	449.10	Pinkish white	205–208	0.59^b	79.6
T₁₁	C₂₄H₃₇ClN₄S	449.10	White	202–205	0.65^b	78.0
T₁₂	C₂₄H₃₆Cl₂N₄S	483.54	White	211–214	0.34^b	74.3
T₁₃	C₂₄H₃₇BrN₄S	493.55	White	197–200	0.39^b	89.2
T₁₄	C₂₄H₃₇BrN₄S	493.55	Brownish yellow	193–196	0.71^b	85.8
T₁₅	C₂₄H₃₇N₅O₂S	459.65	Mustard yellow	195–198	0.68^b	78.9
T₁₆	C₂₄H₃₇N₅O₂S	459.65	Dark yellow	199–202	0.45^b	90.0
T₁₇	C₂₄H₃₇N₅O₂S	459.65	Brown	206–209	0.50^b	85.8
T₁₈	C₂₈H₄₀N₄OS	480.71	Red	186–189	0.67^b	88.8
T₁₉	C₂₆H₄₀N₄OS	440.69	Creamish white	179–182	0.24^b	87.9
T₂₀	C₂₂H₃₆N₄OS	404.61	White	196–199	0.43^b	87.0

ISSN: 2661-801X