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Table 3 Calculated molecular profile for synthesized compounds 10a-m

From: Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease

Compound Descriptor
Mw cLogP H-bond acceptor H-Bond Donor BBB Human intestinal absorption Caco-2 permeability
10a 430.46 3.27 8 0  + 0.9757  + 0.9298 − 0.8029
10b 444.49 3.58 8 0  + 0.9754  + 0.9370 − 0.7985
10c 444.49 3.58 8 0  + 0.9757  + 0.9370 − 0.7908
10d 460.49 3.28 9 0  + 0.9757  + 0.9298 − 0.7587
10e 448.45 3.41 8 0  + 0.9757  + 0.9294 − 0.8157
10f 448.45 3.41 8 0  + 0.9757  + 0.9294 − 0.7970
10g 448.45 3.41 8 0  + 0.9757  + 0.9294 − 0.8152
10h 466.44 3.55 8 0  + 0.9757  + 0.9294 − 0.8211
10i 464.91 3.92 8 0  + 0.9746  + 0.9319 − 0.8289
10j 464.91 3.92 8 0  + 0.9746  + 0.9319 − 0.8211
10k 509.36 4.03 8 0  + 0.9751  + 0.9131 − 0.8299
10l 509.36 4.03 8 0  + 0.9751  + 0.9131 − 0.8115
10m 509.36 4.03 8 0  + 0.9751  + 0.9131 − 0.8306