From: Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease
Samples
% Inhibition self-induced Aβ1–42 aggregation
% Inhibition AChE-induced Aβ aggregation
10h
32.6 ± 2.0 (10 µM) b
29.4 ± 1.5 (100 µM) c
Tacrine
7.6 ± 1.4 (10 µM)
6.7 ± 0.9 (100 µM)
Donepezil
18.1 ± 1.4 (10 µM)
25.2 ± 1.7 (100 µM)