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Table 2 Inhibitory activities of compounds 10h against Aβ1-42 aggregationa

From: Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease

Samples % Inhibition self-induced Aβ1–42 aggregation % Inhibition AChE-induced Aβ aggregation
10h 32.6 ± 2.0 (10 µM) b 29.4 ± 1.5 (100 µM) c
Tacrine 7.6 ± 1.4 (10 µM) 6.7 ± 0.9 (100 µM)
Donepezil 18.1 ± 1.4 (10 µM) 25.2 ± 1.7 (100 µM)
  1. a Values are expressed as means ± SEM of three experiments. b Inhibition of self-induced Aβ1-42 aggregation (25 mM) produced by the test compound at 10 µM concentration. c Co-aggregation inhibition of Aβ1-42 and AChE (2 µM, ratio 100:1) by the test compound at 100 µM