Table 1 Anti-cholinesterase activity of 1,2,3-triazole-dimethylaminoacryloyl-chromenone 10a-m 
Entry | Ar | Product 10 | AChEI IC50 (µM) | BuChEI IC50 (µM) |
|---|---|---|---|---|
1 | C6H5 | 10a | > 100 | 34.41 ± 0.23 |
2 | 2-Me-C6H4 | 10b | > 100 | 35.73 ± 0.21 |
3 | 4-Me-C6H4 | 10c | > 100 | > 100 |
4 | 3-MeO-C6H4 | 10d | > 100 | 23.44 ± 0.07 |
5 | 2-F-C6H4 | 10e | > 100 | > 100 |
6 | 3-F-C6H4 | 10f | > 100 | 59.58 ± 0.05 |
7 | 4-F-C6H4 | 10g | > 100 | > 100 |
8 | 3,4-diF-C6H3 | 10h | > 100 | 21.71 ± 0.57 |
9 | 2-Cl-C6H4 | 10i | > 100 | > 100 |
10 | 4-Cl-C6H4 | 10j | > 100 | > 100 |
11 | 2-Br-C6H4 | 10k | > 100 | > 100 |
12 | 3-Br-C6H4 | 10l | > 100 | 65.96 ± 0.004 |
13 | 4-Br-C6H4 | 10m | > 100 | > 100 |
14 | donepezil | 0.079 ± 0.002 | 5.19 ± 0.38 |