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Table 1 Anti-cholinesterase activity of 1,2,3-triazole-dimethylaminoacryloyl-chromenone 10a-m
figureb

From: Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease

Entry Ar Product 10 AChEI IC50 (µM) BuChEI IC50 (µM)
1 C6H5 10a  > 100 34.41 ± 0.23
2 2-Me-C6H4 10b  > 100 35.73 ± 0.21
3 4-Me-C6H4 10c  > 100  > 100
4 3-MeO-C6H4 10d  > 100 23.44 ± 0.07
5 2-F-C6H4 10e  > 100  > 100
6 3-F-C6H4 10f  > 100 59.58 ± 0.05
7 4-F-C6H4 10g  > 100  > 100
8 3,4-diF-C6H3 10h  > 100 21.71 ± 0.57
9 2-Cl-C6H4 10i  > 100  > 100
10 4-Cl-C6H4 10j  > 100  > 100
11 2-Br-C6H4 10k  > 100  > 100
12 3-Br-C6H4 10l  > 100 65.96 ± 0.004
13 4-Br-C6H4 10m  > 100  > 100
14 donepezil   0.079 ± 0.002 5.19 ± 0.38
  1. Data are expressed as mean ± SD (three independent experiments)