Table 1 Parameters for deposition of PLA/paclitaxel mixed layer film by spin coating and nanofibers by electrospinning

Process parameters for PLA/paclitaxel films by spin coating

Speed (rpm)

3000

Operational temperature (°C)

Room temperature

Deposition time (min)

4

PLA concentration in TFA (wt.%)

40

Paclitaxel concentration in DMSO

2.5 mg/100 μl (50%), 5 mg/100 μl (100%)

Process parameters for PLA/paclitaxel nanofibers by electrospinning

Voltage (kV)

17

Flow rate (μl/min)

1 × 10⁻²

Syringe outer/inner diameter (mm)

5.0 × 10⁻¹/2.6 × 10⁻¹

Operational temperature (°C)

Room temperature

Working distance (cm)

14 or 15

Deposition time (s)

> 60

PLA concentration in TFA (wt.%)

40

Paclitaxel concentration in DMSO

2.5 mg/1 ml (50%), 5 mg/1 ml (100%)

Volumetric mixing ratio (PLA: Paclitaxel)

3 ml: 200 μl