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Table 2 α-Glucosidase and α-amylase inhibitory activity (IC50) of synthesized derivatives (5a5v) and their docking affinity with α-glucosidase (modeled protein) and α-amylase (PDB-1qho)

From: Synthesis, molecular docking and molecular dynamic simulation studies of 2-chloro-5-[(4-chlorophenyl)sulfamoyl]-N-(alkyl/aryl)-4-nitrobenzamide derivatives as antidiabetic agents

Comp. IC50 α-glucosidase (µM) Binding score (α-glucosidase: modeled protein) IC50 α-amylase (µM) Binding score (α-amylase: 1qho)
5a 31.39 ± 1.66 − 9.4 7.40 ± 0.15 − 8.9
5b 24.78 ± 2.69 − 9.7 5.30 ± 1.23 − 9.0
5c 26.77 ± 1.13 − 9.3 8.00 ± 0.71 − 9.8
5d 38.57 ± 0.01 − 9.2 38.00 ± 0.51 − 9.1
5e 41.75 ± 1.08 − 9.3 50.30 ± 0.21 − 8.7
5f 50.24 ± 0.89 − 9.4 16.00 ± 0.33 − 9.7
5g 35.92 ± 0.60 − 9.6 16.70 ± 0.41 − 9.8
5h 40.64 ± 1.49 − 9.6 19.30 ± 0.63 − 9.7
5i 14.02 ± 0.93 − 9.5 27.12 ± 0.51 − 8.5
5j 15.75 ± 0.90 − 9.6 20.90 ± 1.24 − 9.5
5k 36.93 ± 1.30 − 9.7 12.50 ± 0.91 − 8.8
5l 29.01 ± 0.86 − 9.3 6.30 ± 0.42 − 9.3
5m 24.47 ± 1.23 − 9.4 1.52 ± 0.84 − 9.7
5n 29.54 ± 1.53 − 9.4 35.30 ± 0.45 − 9.6
5o 10.75 ± 0.52 − 9.3 00.90 ± 0.31 − 9.2
5p 19.51 ± 0.43 − 9.4 02.10 ± 0.52 − 9.1
5q 43.88 ± 1.18 − 9.4 11.20 ± 0.67 − 9.0
5r 34.36 ± 0.62 − 9.7 15.30 ± 1.24 − 9.4
5s 106.23 ± 0.61 − 8.2 48.05 ± 0.23 − 7.9
5t 130.90 ± 2.42 − 8.6 55.14 ± 0.71 − 8.3
5u 89.04 ± 1.76 − 8.9 38.20 ± 0.34 − 8.6
5v 52.37 ± 1.92 − 9.0 40.40 ± 0.87 − 8.9
Acarbose 39.48 ± 0.88 − 8.0 5.60 ± 0.30 − 8.4