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Table 1 α-Amylase and α-glucosidase inhibition studies of compounds 1–13 with their CDOCKER interaction energy in kJ/mol

From: Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives

No. R α-Amylase inhibition (µg/mL ± SEM) CDOCKER interaction energy in kJ/mol α-Glucosidase inhibition (µg/mL ± SEM) CDOCKER interaction energy in kJ/mol
1 28.89 ± 0.102 − 37.95 28.09 ± 0.09 − 38.30
2 12.91 ± 0.04 − 42.02 12.72 ± 0.12 − 42.16
3 28.84 ± 0.03 − 37.45 28.61 ± 0.11 − 37.87
4 12.17 ± 0.14 − 43.02 12.01 ± 0.09 − 43.23
5 13.57 ± 0.17 − 39.45 13.68 ± 0.36 − 39.05
6 13.01 ± 0.07 − 40.56 13.11 ± 0.15 − 39.42
7 12.91 ± 0.08 − 42.01 12.79 ± 0.17 − 42.31
8 13.04 ± 0.02 − 40.19 12.99 ± 0.09 − 41.03
9 26.53 ± 0.08 − 40.20 26.27 ± 0.18 − 40.95
10 26.7 ± 0.06 − 39.85 25.97 ± 0.19 − 40.82
11 26.94 ± 0.02 − 39.85 27.02 ± 0.11 − 40.03
12 37.33 ± 0.02 − 39.89 38.01 ± 0.12 − 39.48
13 36.65 ± 0.03 − 39.76 37.47 ± 0.13 − 39.38
Acarbose   10.98 ± 0.03 − 44.30 10.79 ± 0.17 − 44.79