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Table 1 α-Amylase and α-glucosidase inhibition studies of compounds 1–13 with their CDOCKER interaction energy in kJ/mol

From: Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives

No.

R

α-Amylase inhibition (µg/mL ± SEM)

CDOCKER interaction energy in kJ/mol

α-Glucosidase inhibition (µg/mL ± SEM)

CDOCKER interaction energy in kJ/mol

1

28.89 ± 0.102

− 37.95

28.09 ± 0.09

− 38.30

2

12.91 ± 0.04

− 42.02

12.72 ± 0.12

− 42.16

3

28.84 ± 0.03

− 37.45

28.61 ± 0.11

− 37.87

4

12.17 ± 0.14

− 43.02

12.01 ± 0.09

− 43.23

5

13.57 ± 0.17

− 39.45

13.68 ± 0.36

− 39.05

6

13.01 ± 0.07

− 40.56

13.11 ± 0.15

− 39.42

7

12.91 ± 0.08

− 42.01

12.79 ± 0.17

− 42.31

8

13.04 ± 0.02

− 40.19

12.99 ± 0.09

− 41.03

9

26.53 ± 0.08

− 40.20

26.27 ± 0.18

− 40.95

10

26.7 ± 0.06

− 39.85

25.97 ± 0.19

− 40.82

11

26.94 ± 0.02

− 39.85

27.02 ± 0.11

− 40.03

12

37.33 ± 0.02

− 39.89

38.01 ± 0.12

− 39.48

13

36.65 ± 0.03

− 39.76

37.47 ± 0.13

− 39.38

Acarbose

 

10.98 ± 0.03

− 44.30

10.79 ± 0.17

− 44.79