Bioactive fluorenes. Part III: 2,7-dichloro-9H-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents

Table 9 In vitro cytotoxic screening of 6a–n against MDA-MB-231 human breast cancer cells

Comp.	Validity (%) for sample Concentrations (µg/mL)								IC₅₀ (µg/mL)
Comp.	0	1	10	31.25	62.50	125	250	500	IC₅₀ (µg/mL)
6a	100	99.4	92.4	90.7	83.1	78.3	69.6	63.2	612
6b	100	95.9	93.4	89.7	84.2	79.8	72.9	68.9	749
6c	100	92.8	77.8	63.1	53.1	46.04	29.4	24.8	104
6d	100	93.3	89.1	75.8	63.3	53.1	27.7	24.00	169
6e	100	98.2	90.2	89.9	85.2	69.2	41.9	39.4	215
6f	100	91.8	89.6	83.00	72.4	59.7	37.2	28.9	188
6g	100	96.7	93.9	91.2	82.9	71.1	65.5	55.6	576
6h	100	94.3	90.4	85.8	77.8	73.6	68.5	65.8	685
6i	100	94.2	89.1	66.8	55.9	49.2	24.3	18.2	120
6j	100	96.3	92.9	75.6	73.1	69.01	53.2	50.6	508
6k	100	96.4	90.7	78.6	69.6	51.00	33.3	19.1	131
6l	100	96.9	90.4	85.5	71.9	69.8	66.7	60.9	603
6m	100	93.2	89.9	77.6	73.2	67.1	63.4	59.5	590
6n	100	96.2	89.5	86.8	81.3	73.2	67.1	59.2	584

ISSN: 2661-801X