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Table 7 In vitro cytotoxic screening of 6a–n against WI-38 human normal fibroblast cells

From: Bioactive fluorenes. Part III: 2,7-dichloro-9H-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents

Comp.

Validity (%) for sample concentrations (µg/mL)

IC50 (µg/mL)

0

31.25

62.50

125

250

500

6a

100

71.1

66.1

59.1

49.1

47.1

241

6b

100

94.1

87.9

71.6

62.6

57.7

520

6c

100

94.5

65.9

63.4

59.5

55.5

515

6d

100

92.01

88.1

78.6

67.5

67.7

759

6e

100

68.8

52.5

45.6

38.6

26.8

65.4

6f

100

49

44.8

35.6

32.3

30.4

29

6g

100

73.9

42.00

37.4

35.7

30.6

40

6h

100

85.01

70.6

60.4

51.8

49.4

487

6i

100

83.1

76.5

56.5

49.2

39.2

240

6j

100

87.3

81.4

66.3

60.9

37.2

356

6k

100

77.9

64.03

61.3

60.3

58.3

528

6l

100

94.01

76.4

70.2

52.5

39.02

350

6m

100

78.5

72.8

68.5

63.00

55.7

512

6n

100

98.6

85.9

53.2

43.3

39.8

212