Skip to main content

Table 4 In vitro cytotoxic screening of 5a–n against WI-38 human normal fibroblast cells

From: Bioactive fluorenes. Part III: 2,7-dichloro-9H-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents

Comp.

Validity (%) for sample concentrations (µg/mL)

IC50 (µg/mL)

0

31.25

62.50

125

250

500

5a

100

89.8

83.3

80.6

77.3

74.3

1061

5b

100

99.4

94.4

91.3

81.2

79.00

1173

5c

100

89.7

87.3

83.8

77.5

71.3

996

5d

100

94.9

88.5

86.09

50.7

44.2

268

5e

100

92.4

85.7

74.4

69.3

62.9

854

5f

100

82.5

81.9

76.97

74.3

67.8

948

5g

100

96.7

95.1

90.2

85.8

79.2

1193

5h

100

94.97

81.7

78.7

72.8

66.2

900

5i

100

88.2

86.9

69.1

63.1

59.3

796

5j

100

84.2

66.1

61.5

39.1

38.5

196

5k

100

80.8

71.4

64.8

51.4

41.9

288

5l

100

70.5

60.6

57.2

48.1

39.5

223

5m

100

68.5

64.6

42.3

40.3

26.5

92

5n

100

54.3

51.5

50.8

46.4

40.5

130