Table 3 Determination of minimum inhibitory concentration (MIC) of the most active newly synthesized fluorene derivatives 5a–n and 6a–n
Comp. | Tested strain/MIC (µg/mL) | ||||
|---|---|---|---|---|---|
S. aureus | MRSA | E. coli | K. pneumoniae | P. aeruginosa | |
5h | 62.5 | – | – | – | – |
5j | – | – | 62.5 | – | 62.5 |
6c | – | – | 62.5 | 125 | – |
6e | 62.5 | – | – | – | – |
6h | 62.5 | 31.25 | 31.25 | – | – |
6j | – | – | 31.25 | – | – |
6k | – | – | 31.25 | – | 125 |
6l | 31.25 | 31.25 | 31.25 | – | 125 |
6m | – | – | 15.6 | – | – |
6n | – | – | 31.25 | – | 62.5 |
Gentamicin 10 µg/mL | – | – | 0.3 | 0.3 | 0.3 |
Vancomycin 50 µg/mL | 0.7 | 0.7 | – | – | – |
DMSO | – | – | – | – | – |