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Table 2 Antimicrobial activity of the newly synthesized azetidinone derivatives 6a–n against the multidrug resistant tested microbial strains

From: Bioactive fluorenes. Part III: 2,7-dichloro-9H-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents

Comp.

Gram (+ve) bacteria

Gram (−ve) bacteria

Fungi

S. aureus

MRSA

S. pneumoniae

E. coli

K. pneumoniae

P. aeruginosa

A. baumannii

A. flavus

A. niger

C. albicans

6a

5

–

–

13

–

–

–

–

–

–

6b

–

–

–

12

–

–

–

–

–

–

6c

7

–

–

15

6

10

–

–

–

–

6d

3

–

–

5

5

8

–

–

–

–

6e

12

–

–

–

–

–

–

–

–

–

6f

10

–

–

–

–

–

5

–

–

–

6g

–

–

–

–

–

–

–

–

–

–

6h

12

15

–

15

3

–

–

–

–

–

6i

–

–

–

12

3

–

–

–

–

–

6j

9

–

–

20

–

–

6

–

–

–

6k

7

–

–

14

3

11

–

–

–

–

6l

15

15

–

22

–

8

–

–

–

–

6m

4

6

–

27

3

–

–

–

–

–

6n

9

–

–

19

5

13

5

–

–

–

PC

28

26

20

28

20

30

20

18

18

20

  1. Mean zone of inhibition in mm, – = resistant
  2. PC positive control (Vancomycin 50 µg/mL for Gram-positive bacteria and Gentamicin 10 µg/mL for Gram-negative bacteria), fluconazole 25 µg/mL for fungi