Table 5 ADMET profile of various newly synthesized naringenin derivatives
Compound(s) | Mol. Wt. | No. of rotatable bond | DonorHB | AcceptHB | QPlogPo/w | QPlogBB | QPPMDCK | QPPCaco |
|---|---|---|---|---|---|---|---|---|
Compound 1 | 392.10 | 5 | 5 | 4 | 2.084 | 0.081 | 0.053 | 1.877 |
Compound 2 | 345.12 | 3 | 3 | 3 | 2.490 | 0.138 | 11.251 | 2.773 |
Compound 3 | 365.11 | 4 | 2 | 4 | 4.29 | 2.445 | 0.282 | 10.982 |
Compound 4 | 381.08 | 3 | 4 | 2 | 1.278 | 3.355 | 0.162 | 20.169 |