Scheme 2From: Synthesis of some novel 2-(3-cyano -6-(thiophen- 2-yl)-4,4′- bipyridin-2- yloxy)acetohydrazide derivatives: assessment of their cytotoxic activitySynthesis of pyrazole derivatives (4-6). Reagents and conditions :(i) ethyl acetoacetate/AcOH,reflux;(ii) diethyl malonate/AcOH or ethyl cyanoacetate/AcOH, reflux; (iii) acetylacetone/AcOH refluxBack to article page