Optimization of Eugenia punicifolia (Kunth) D. C. leaf extraction using a simplex centroid design focused on extracting phenolics with antioxidant and antiproliferative activities

Table 2 ANOVA results for response surface models used subsequently in optimizing TPC, TFC, EC₅₀, HEp-2 and MVC on the extraction parameters from E. punicifolia leaves

TPC			TFC		EC₅₀		HEp-2		MVC
	Linear model	Lack of fit	Linear model	Lack of fit	Reduced quadratic model	Lack of Fit	Linear model	Lack of fit	Reduced model	Lack of Fit
F	13.60	1.36	23.94	1.60	11.13	1.84	30.46	1.83	23.99	1.40
p	0.0019	0.4179	0.0002	0.3794	0.0032	0.3937	0.0002	0.3941	0.0018	0.4074
R²	0.7514		0.8272		0.8067		0.8839		0.9320
AdjR²	0.6962		0.7835		0.7342		0.8549		0.8931
CV (%)	2.57		4.53		14.64		10.37		6.73

ISSN: 2661-801X