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Table 1 Biological evaluation of the inhibitory activity of (E)-Nʹ-benzylidene-4-hydroxy-3-methoxybenzohydrazide derivatives and kojic acid against tyrosinase enzyme in the presence of L-DOPA as the substrate
figurea

From: Synthesis, biological evaluation and molecular docking analysis of vaniline–benzylidenehydrazine hybrids as potent tyrosinase inhibitors

CompoundsRIC50 (µM)aCompoundsRIC50 (µM) a
4a37.09 ± 1.024g4.58 ± 1.23
4b15.21 ± 1.344h10.00 ± 1.6
4c35.63 ± 2.84i1.58 ± 2.76
4d20.95 ± 2.094j17.01 ± 2.03
4e1.95 ± 2.344k5.84 ± 1.9
4f29.06 ± 0.89Kojic acidb 9.3 ± 1.27
  1. aData presented here are the mean ± SEM of three to five independent experiments
  2. bReference compound