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Table 1 Biological evaluation of the inhibitory activity of (E)-Nʹ-benzylidene-4-hydroxy-3-methoxybenzohydrazide derivatives and kojic acid against tyrosinase enzyme in the presence of L-DOPA as the substrate
figure a

From: Synthesis, biological evaluation and molecular docking analysis of vaniline–benzylidenehydrazine hybrids as potent tyrosinase inhibitors

Compounds

R

IC50 (µM)a

Compounds

R

IC50 (µM) a

4a

37.09 ± 1.02

4g

4.58 ± 1.23

4b

15.21 ± 1.34

4h

10.00 ± 1.6

4c

35.63 ± 2.8

4i

1.58 ± 2.76

4d

20.95 ± 2.09

4j

17.01 ± 2.03

4e

1.95 ± 2.34

4k

5.84 ± 1.9

4f

29.06 ± 0.89

Kojic acidb

 

9.3 ± 1.27

  1. aData presented here are the mean ± SEM of three to five independent experiments
  2. bReference compound
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BMC Chemistry

ISSN: 2661-801X

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