Table 4 Anti-inflammatory activities for compounds 7a–k, 8a–c, 9a–c and reference drug in carrageen-induced rat paw edema test

Control

2.624 ± 0.255

2.232 ± 0.235

1.875 ± 0.181

Indomethacin

70.7

96

96.6

0.768 ± 0.050

0.075 ± 0.007

0.075 ± 0.004

Celecoxib

68.9

95.5

94.7

0.810 ± 0.074

0.100 ± 0.009

0.100 ± 0.005

7a

74.1

88.7

92

0.679 ± 0.03

0.250 ± 0.021

0.151 ± 0.007

7b

76.1

91.2

93.5

0.627 ± 0.045

0.196 ± 0.017

0.123 ± 0.009

7c

62.7

81.2

82.5

0.978 ± 0.071

0.419 ± 0.028

0.331 ± 0.011

7d

51.6

77.5

78.6

1.270 ± 0.015

0.502 ± 0.044

0.405 ± 0.018

7e

53.9

71.1

79.9

1.209 ± 0.11

0.645 ± 0.01

0.381 ± 0.007

7f

60.5

72.7

79.2

1.036 ± 0.009

0.609 ± 0.03

0.394 ± 0.01

7g

58.5

72.3

67.4

1.088 ± 0.090

0.618 ± 0.010

0.618 ± 0.045

7h

75.4

89.4

92.7

0.645 ± 0.058

0.236 ± 0.008

0.138 ± 0.006

7i

73.1

94.3

90.1

0.705 ± 0.047

0.127 ± 0.009

0.187 ± 0.015

7j

64.3

78.6

71

0.936 ± 0.064

0.477 ± 0.027

0.549 ± 0.013

7k

55.7

69.1

66.3

1.162 ± 0.088

0.689 ± 0.011

0.638 ± 0.051

8a

52.5

58

56.4

1.246 ± 0.076

0.937 ± 0.046

0.826 ± 0.078

8b

52.1

68.1

76.2

1.256 ± 0.074

0.712 ± 0.066

0.451 ± 0.013

8c

67.9

71.9

74.2

0.842 ± 0.062

0.627 ± 0.05

0.489 ± 0.032

9a

77.2

61.8

62.3

0.598 ± 0.050

0.852 ± 0.073

0.714 ± 0.052

9b

66.2

80.5

73.4

1.175 ± 0.057

0.700 ± 0.024

0.726 ± 0.055

9c

55.2

68.6

61.7

0.886 ± 0.077

0.435 ± 0.033

0.504 ± 0.009