Skip to main content

Table 2 Minimum inhibitory concentrations (MIC µg/mL) of most active compounds 7a, 7g, 7i and reference drugs, ceftriaxone and amphotericin B

From: Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities

Compound No.

Saa

Ecb

Kpc

Pad

Abe

Caf

Cng

CCh50

HCi10

7a

8

≤ 0.25

8

4

16

> 32

> 32

> 32

> 32

7g

1

≤ 0.25

1

1

4

> 32

> 32

4.2

> 32

7i

2

≤ 0.25

2

2

4

> 32

> 32

2.987

> 32

Ceftriaxone

32

0.125

16

32

32

NTj

NT

NT

NT

Amphotericin B

NT

NT

NT

NT

NT

1.56

1.56

NT

NT

  1. aMRSA
  2. bE. coli
  3. cK. pneumoniae
  4. dP. aeruginosa
  5. eA. baumannii
  6. fC. albicans
  7. gC. neoformans var. grubii
  8. hCC50 is the concentration at 50% cytotoxicity
  9. iHC10 is the concentration at 10% hemolysis
  10. jNot tested
Back to article page

BMC Chemistry

ISSN: 2661-801X

Contact us