Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities

Table 1 The antibacterial and antifungal activities (growth inhibition %) for compounds 7a–k, 8a–c and 9a–c at 32 µg/mL concentration

Compound No.	Sa^a	Ec^b	Kp^c	Pa^d	Ab^e	Ca^f	Cn^g
7a	95.76	96.48	97.64	97.76	96.66	6.28	− 64.35
7b	25.62	− 8.09	− 5.34	3.8	35.54	9.55	− 280.7
7c	21.88	3.17	12.8	11.3	43.29	4.13	− 110.9
7d	15.6	− 5.77	4.86	− 8.11	34.95	2.54	− 177.2
7e	7.58	− 11.49	− 14.6	− 22.55	43.64	28.66	− 59.93
7f	8.33	− 9.43	8.05	− 7.9	66.69	3.5	− 118.8
7g	96.15	86.42	87.53	94.63	85.76	4.88	− 57.42
7h	30.26	− 13.86	23.59	7.97	51.82	25.34	− 99
7i	95.22	96.45	94.4	96.93	94.34	15.32	− 104.5
7j	30.59	− 2.24	12.27	− 0.85	46.23	1.91	− 80.19
7k	28.25	− 0.72	8.77	2.23	31.42	1.79	− 55.44
8a	13.6	− 45.65	− 22.34	− 28.34	− 15.51	7.71	− 292.1
8b	11.28	− 8.78	6.56	14.46	22.42	13.22	− 114.4
8c	4.62	− 25.19	− 8.38	− 10	− 13.94	1.65	− 288.1
9a	− 3.37	− 12.05	14.84	2.49	42.1	9.15	− 254
9b	10.33	− 5.88	9.23	7.9	33.26	2.47	− 119.3
9c	− 2.72	− 15.45	1.19	− 0.83	33.66	4.88	− 136.1

ISSN: 2661-801X