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Table 1 Antiproliferative activities of resveratrol and its analogs compound 1–4 in cell lines

From: Finding an efficient tetramethylated hydroxydiethylene of resveratrol analogue for potential anticancer agent

Compounds

IC50 (μM)a

Clogp[b]

MCF-7

HeLa

H1299

MRC-5

UC2

1

8.01 ± 0.35

8.36 ± 0.20

9.64 ± 0.48

18.67 ± 0.93

24.87 ± 2.62

5.496

2

13.16 ± 0.65

>80

45.28 ± 1.65

>80

68.73 ± 2.59

5.296

3

28.36 + 3.30

48.13 ± 0.95

28.87 ± 3.54

72.10 ± 3.18

46.97 ± 5.90

5.396

4

10.14 ± 1.59

9.85 ± 1.07

22.51 ± 2.84

24.02 ± 0.83

26.67 ± 0.83

5.296

RES

>80

>80

47.63 ± 1.62

51.3 ± 0.5

45.12 ± 4.65

2.833

  1. aThe results are presented as the mean ± SD for 4 replications in 3 separate trials after treatment with compounds for 72 h
  2. bCalculated by Bio-Loom software [14]
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BMC Chemistry

ISSN: 2661-801X

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