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Table 4 Comparison of three-component reaction of benzyl bromide, sodium azide and phenyl acetylene under different condition using different catalysts

From: Magnetic γFe2O3@Sh@Cu2O: an efficient solid-phase catalyst for reducing agent and base-free click synthesis of 1,4-disubstituted-1,2,3-triazoles

EntryCatalyst and catalyst loadingSolventConditionTime (min)Yield (%)TONTOFRefs.
1NiFe2O4-glutamate-Cu (1 mol%)H2Or.t240929.2 * 1032.3 * 103[5]
2CuNPs@agarose (0.05 mol%)H2O40 °C480961.9 * 1052.4 * 104[7]
3OSPs-CuBra (1 mol%)H2O70 °C240919.1 * 1032.2 * 103[8]
4Cu/cb (5 mol%)H2O100 °C40921.8 * 1032.8 * 103[9]
5Cu catc (0.25 mol%)
Sodium ascorbate (10 mol%)
t-BuOH: H2O (1:3)50 °C90993.9 * 1042.6 * 104[17]
6MNPs@FGlyd (0.5 mol%)
Sodium ascorbate
t-BuOH: H2O60 °C240991.9 * 1044.9 * 103[19]
7Cu/SDe (6 mol%)H2OSonication15951.6 * 1036.3 * 103[51]
8γFe2O3@Sh@Cu2O (0.025 mol%)H2O:EtOH (1:1)60 °C20933.7 * 1051.0 * 106This work
  1. aOyster shell powders
  2. bCu(I) on charcoal
  3. cSelf-assembled polymeric imidazole-copper catalyst
  4. dFe3O4-silicacoated@functionalized 3-glycidoxypropyltrimethoxysilane
  5. eCopper/sandarac