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Table 2 Screening catalysts for the three-component reaction of benzyl bromide, sodium azide and phenyl acetylene

From: Magnetic γFe2O3@Sh@Cu2O: an efficient solid-phase catalyst for reducing agent and base-free click synthesis of 1,4-disubstituted-1,2,3-triazoles

Entry

Catalyst (30 mg)

Time

Isolated yield

1

Fe3O4

5 h

2

Sh

5 h

3

Fe3O4@Sh

5 h

4

γFe2O3@Sh@Cu2O

20 min

94

5

HA

5 h

Trace

6

Fe3O4@HA

5 h

15

7

Fe3O4@HA@Cu

45 min

90

8

Cu2Fe2O4, sodium ascorbate

5 h

15

9

CuBr2

5 h

Trace

  1. Experimental conditions: benzyl bromide (1.3 mmol), phenyl acetylene (1.0 mmol), sodium azide (1.3 mmol), catalyst (30 mg), solvent (H2O:EtOH 2 mL), 60 °C