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Table 2 Screening catalysts for the three-component reaction of benzyl bromide, sodium azide and phenyl acetylene

From: Magnetic γFe2O3@Sh@Cu2O: an efficient solid-phase catalyst for reducing agent and base-free click synthesis of 1,4-disubstituted-1,2,3-triazoles

EntryCatalyst (30 mg)TimeIsolated yield
1Fe3O45 h
2Sh5 h
3Fe3O4@Sh5 h
4γFe2O3@Sh@Cu2O20 min94
5HA5 hTrace
6Fe3O4@HA5 h15
7Fe3O4@HA@Cu45 min90
8Cu2Fe2O4, sodium ascorbate5 h15
9CuBr25 hTrace
  1. Experimental conditions: benzyl bromide (1.3 mmol), phenyl acetylene (1.0 mmol), sodium azide (1.3 mmol), catalyst (30 mg), solvent (H2O:EtOH 2 mL), 60 °C