Benzimidazole Schiff base derivatives: synthesis, characterization and antimicrobial activity

BMC Chemistry

Table 4 Antibacterial activity of the Schiff bases 3.a–f

Minimum inhibitory concentration MIC (µg/mL)
Compounds	Gram positive						Gram negative
Compounds	BS	EF	SE	SA	BC	MS	ECL	EM	KO	EA	PM	PA	KP	EC
3.a	125	250	15.6	31.2	250	250	250	125	62.5	250	250	250	15.6	7.8
3.b	62.5	125	15.6	31.2	125	125	250	125	125	125	125	125	62.5	31.2
3.c	125	125	7.8	31.2	125	125	125	125	125	125	125	125	7.8	7.8
3.d	125	250	7.8	250	250	250	250	250	31.2	125	250	250	7.8	7.8
3.e	125	125	7.8	125	125	62.5	250	125	62.5	125	125	250	7.8	7.8
3.f	125	125	7.8	31.2	125	31.2	125	125	62.5	125	250	125	7.8	7.8
STM	16	128	8	256	32	4	512	128	16	16	128	16	64	64
NLD	16	> 512	64	64	32	512	16	128	8	256	32	128	64	512

STM, streptomycin; NLD, nalidixic acid, BC, Bacillus cereus; BS, B. subtilis; EF, Enterococcus faecalis; MS, Mycobacterium smegmatis; SE, Staphylococcus epidermidis; SA, S. aureus; ECL, Enterobacter cloacae; EC, Escherichia coli; EA, Enterobacter aerogenes; PV, Proteus vulgaris; KO, Klebsiella oxytoca; KP, K. pneumonia; PM, Proteus mirabilis; PA, Pseudomonas aeruginosa

ISSN: 2661-801X