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Table 6 The physicochemical properties of synthesized bisarylic derivatives A1 to A5

From: gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect

Compound IUPAC
Name
Aspect Mass of the starting material (mg) Mass of the product Rf value (PE:EtOAc) m.p. (oC) % yield
A1 2-(3-(2-benzoyl-4,5-dimethylbenzoyl)phenyl)propanoic acid White solid 270 225 0.17 (5:5) 86–88 80
A2 2-(3-(difluoro(2-(methoxycarbonyl)-4,5-dimethylphenyl)methyl)phenyl)propanoic acid White solid 74 60 0.40 (9.5:0.5) 98–100 78
A3 2-((3-bromophenyl)difluoromethyl)-4,5-dimethylbenzoic acid White solid 100 83 0.28 (6:4) 64–66 80
A4 2-((3-acetylphenyl)difluoromethyl)-4,5-dimethylbenzoic acid White solid 103 80 0.38 (8:2) 118–120 74
A5 2-(difluoro(3-isopropylphenyl)methyl)-4,5-dimethylbenzoic acid White solid 100 55 0.26 (7:3) 152–154 53