Table 6 The physicochemical properties of synthesized bisarylic derivatives A1 to A5
From: gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect
Compound | IUPAC Name | Aspect | Mass of the starting material (mg) | Mass of the product | Rf value (PE:EtOAc) | m.p. (oC) | % yield |
|---|---|---|---|---|---|---|---|
A1 | 2-(3-(2-benzoyl-4,5-dimethylbenzoyl)phenyl)propanoic acid | White solid | 270 | 225 | 0.17 (5:5) | 86–88 | 80 |
A2 | 2-(3-(difluoro(2-(methoxycarbonyl)-4,5-dimethylphenyl)methyl)phenyl)propanoic acid | White solid | 74 | 60 | 0.40 (9.5:0.5) | 98–100 | 78 |
A3 | 2-((3-bromophenyl)difluoromethyl)-4,5-dimethylbenzoic acid | White solid | 100 | 83 | 0.28 (6:4) | 64–66 | 80 |
A4 | 2-((3-acetylphenyl)difluoromethyl)-4,5-dimethylbenzoic acid | White solid | 103 | 80 | 0.38 (8:2) | 118–120 | 74 |
A5 | 2-(difluoro(3-isopropylphenyl)methyl)-4,5-dimethylbenzoic acid | White solid | 100 | 55 | 0.26 (7:3) | 152–154 | 53 |