TY - JOUR AU - Cui, Xin AU - Du, Junming AU - Jia, Zongqing AU - Wang, Xilong AU - Jia, Haiyong PY - 2019 DA - 2019/10/31 TI - A green and facile synthesis of an industrially important quaternary heterocyclic intermediates for baricitinib JO - BMC Chemistry SP - 123 VL - 13 IS - 1 AB - Baricitinib, with a 2-(1-(ethylsulfonyl)azetidin-3-yl)acetonitrile moiety at N-2 position of the pyrazol skeleton, is an oral and selective reversible inhibitor of the JAK1 and JAK2 and displays potent anti-inflammatory activity. Several research-scale synthetic methods have been reported for the preparation of key quaternary heterocyclic intermediates of baricitinib. However, they were all associated with several drawbacks, such as the expensive materials, usage of pollutional reagents, and poor yields. SN - 2661-801X UR - https://doi.org/10.1186/s13065-019-0639-y DO - 10.1186/s13065-019-0639-y ID - Cui2019 ER -