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Table 2 Optimization of reaction conditions

From: Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) tethered to nano-Fe3O4 as a superior catalyst for the synthesis of 1,3-thiazoles

Entry

Solvent (reflux)

Catalyst

Time (min)

Yield (%)a

1

EtOH

–

500

39

2

EtOH

CAN (7 mol%)

250

53

3

EtOH

NaHSO4 (5 mol%)

300

45

4

EtOH

InCl3 (4 mol%)

200

56

5

EtOH

ZrO2 (6 mol%)

250

60

6

EtOH

p-TSA (3 mol%)

200

64

7

EtOH

Nano-Fe3O4 (10 mg)

200

52

8

EtOH

Cross-PAA-SO3H (10 mg)

150

56

9

EtOH

nano-Fe3O4 (5 mg) + Cross-PAA-SO3H (5 mg)

150

60

10

H2O

Cross-PAA-SO3H@nano-Fe3O4 (7 mg)

150

77

11

DMF

Cross-PAA-SO3H@nano-Fe3O4 (7 mg)

150

82

12

CH3CN

Cross-PAA-SO3H@nano-Fe3O4 (7 mg)

150

89

13

EtOH

Cross-PAA-SO3H@nano-Fe3O4 (5 mg)

150

92

14

EtOH

Cross-PAA-SO3H@nano-Fe3O4 (7 mg)

150

94

15

EtOH

Cross-PAA-SO3H@nano-Fe3O4 (9 mg)

150

94

  1. Phenacyl bromide (1 mmol), carbon disulfide (1 mmol) and benzyl amine (1 mmol)
  2. aIsolated yield