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Table 1 The effect of solvents on the model reaction in the presence of Fe3O4@l-arginine

From: Green synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazoles] using Fe3O4@l-arginine as a robust and reusable catalyst

Entry

Solvent

Time (min)

Yield (%)a

1

EtOH (reflux)

70

60

2

DMF (reflux)

120

50

3

H2O (reflux)

130

35

4

CH3CN (reflux)

120

45

5

Toluene (reflux)

240

25

6

Solvent-free (r.t.)

60

96

7

Solvent-free (40 °C)

60

95

8

Solvent-free (80 °C)

60

96

  1. Reaction conditions: hydrazine monohydrate, isatin, ethyl acetoacetate, malononitrile (molar ratio: 1:1: 1.2:1) using (0.01 g) of Fe3O4@l-arginine
  2. aIsolated yields
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BMC Chemistry

ISSN: 2661-801X

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