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Table 8 Precision data for the determination of VPS by Method 2

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Parameters Column (A) Column (B)
Concentration (ng/mL) Concentration (ng/mL)
30 70 150 30 70 150
Intraday
 % Found 95.70 99.06 99.83 101.05 99.51 99.77
93.62 97.15 99.76 92.25 96.37 97.52
100.94 100.58 99.79 95.06 97.59 99.50
 (\( \overline{{\text{x}}} \)) 96.75 98.93 99.79 96.12 97.82 98.93
 ± SD 3.77 1.72 0.04 4.50 1.58 1.23
 %RSD 3.90 1.74 0.04 4.68 1.62 1.24
 %Error 2.25 1.00 0.02 2.70 0.93 0.72
Inter-day
 % Found 98.69 97.19 99.92 100.19 98.41 100.21
101.55 98.21 100.13 96.79 103.68 97.25
97.43 98.37 99.87 97.74 98.49 99.77
 (\( \overline{{\text{x}}} \)) 99.22 97.92 99.97 98.24 100.19 99.80
 ± SD 2.11 0.64 0.14 1.75 3.02 1.60
 %RSD 2.13 0.65 0.14 1.79 3.01 1.61
 %Error 1.23 0.38 0.08 1.03 1.74 0.93
  1. Each result is the average of three separate determinations