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Table 8 Precision data for the determination of VPS by Method 2

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Parameters

Column (A)

Column (B)

Concentration (ng/mL)

Concentration (ng/mL)

30

70

150

30

70

150

Intraday

 % Found

95.70

99.06

99.83

101.05

99.51

99.77

93.62

97.15

99.76

92.25

96.37

97.52

100.94

100.58

99.79

95.06

97.59

99.50

 (\( \overline{{\text{x}}} \))

96.75

98.93

99.79

96.12

97.82

98.93

 ± SD

3.77

1.72

0.04

4.50

1.58

1.23

 %RSD

3.90

1.74

0.04

4.68

1.62

1.24

 %Error

2.25

1.00

0.02

2.70

0.93

0.72

Inter-day

 % Found

98.69

97.19

99.92

100.19

98.41

100.21

101.55

98.21

100.13

96.79

103.68

97.25

97.43

98.37

99.87

97.74

98.49

99.77

 (\( \overline{{\text{x}}} \))

99.22

97.92

99.97

98.24

100.19

99.80

 ± SD

2.11

0.64

0.14

1.75

3.02

1.60

 %RSD

2.13

0.65

0.14

1.79

3.01

1.61

 %Error

1.23

0.38

0.08

1.03

1.74

0.93

  1. Each result is the average of three separate determinations