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Table 7 Precision data for the determination of VPS by Method 1

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Parameters Column (A) Column (B)
Concentration (ng/mL) Concentration (ng/mL)
1.0 3.0 5.0 2.5 5.0 10.0
Intraday
 % Found 96.83 98.30 99.75 94.23 93.28 99.21
97.78 98.77 99.71 92.00 91.55 98.72
94.82 97.66 99.52 93.23 96.26 98.60
 (\( \overline{{\text{x}}} \)) 96.48 98.24 99.66 93.15 93.70 98.84
 ± SD 1.51 0.56 0.12 1.12 2.38 0.32
 %RSD 1.5.7 0.57 0.12 1.2 2.54 0.33
 %Error 0.9 0.33 0.07 0.69 1.47 0.19
Inter-day
 % Found 98.24 98.30 99.72 92.97 96.61 99.30
99.44 96.31 100.42 100.22 99.13 100.66
99.44 96.31 100.42 93.72 99.51 99.79
 (\( \overline{{\text{x}}} \)) 99.04 96.97 100.19 95.46 98.42 99.92
 ± SD 0.69 1.15 0.40 3.99 1.58 0.69
 %RSD 0.70 1.19 0.40 4.17 1.60 0.69
 %Error 0.40 0.68 0.23 2.41 0.92 0.40
  1. Each result is the average of three separate determinations