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Table 5 Application of Method 1 for the analysis of VPS in its pure forms

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Studied drug

Proposed method

Comparison method [11]

Amount taken (ng/mL)

Amount found (ng/mL)

% Found

% Found

Column (A)

Column (B)

Column (A)

Column (B)

Column (A)

Column (B)

VPS

1.0

2.5

1.016

2.469

101.64

98.79

101.12

2.0

3.5

1.989

3.551

99.47

101.47

102.45

3.0

5.0

2.987

4.980

99.57

99.60

99.78

4.0

7.5

3.992

7.497

99.80

99.96

101.77

5.0

10.0

5.015

10.002

100.30

100.02

99.14

Mean

    

100.16

99.97

100.85

± SD

    

0.89

0.97

1.37

t-test

    

0.95

1.17

(2.31)*

F-test

    

2.39

1.99

(6.39)*

  1. Each result is the average of three separate determinations
  2. * Figures between parentheses are the tabulated t and F values at P = 0.05 [17]