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Table 5 Application of Method 1 for the analysis of VPS in its pure forms

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Studied drug Proposed method Comparison method [11]
Amount taken (ng/mL) Amount found (ng/mL) % Found % Found
Column (A) Column (B) Column (A) Column (B) Column (A) Column (B)
VPS 1.0 2.5 1.016 2.469 101.64 98.79 101.12
2.0 3.5 1.989 3.551 99.47 101.47 102.45
3.0 5.0 2.987 4.980 99.57 99.60 99.78
4.0 7.5 3.992 7.497 99.80 99.96 101.77
5.0 10.0 5.015 10.002 100.30 100.02 99.14
Mean      100.16 99.97 100.85
± SD      0.89 0.97 1.37
t-test      0.95 1.17 (2.31)*
F-test      2.39 1.99 (6.39)*
  1. Each result is the average of three separate determinations
  2. * Figures between parentheses are the tabulated t and F values at P = 0.05 [17]
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