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Table 4 Analytical performance data for the determination of SFV by Method 2

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Parameter SFV VPS
Column (A) Column (B) Column (A) Column (B)
Linearity and range (ng/mL) 120–600 120–600 30–150 30–150
Correlation coefficient (r) 1.0000 1.0000 0.9998 0.9999
Slope 0.029 0.029 0.013 0.038
Intercept − 0.009 − 0.016 − 0.003 − 0.063
Sy/x
SD of the residuals
0.036 0.023 0.014 0.011
Sa
SD of the intercept
0.034 0.022 0.014 0.010
Sb
SD of the slope
0.0001 0.0001 0.0002 0.0001
SD 0.48 0.28 2.16 0.25
%RSDa 0.483 0.283 2.156 0.252
%Errorb 0.216 0.127 0.965 0.113
LODc 3.94 2.47 3.41 0.90
LOQd 11.94 7.47 10.33 2.74
  1. aPercentage relative standard deviation
  2. bPercentage relative error
  3. cLimit of detection
  4. dLimit of quantitation