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Table 4 Analytical performance data for the determination of SFV by Method 2

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Parameter

SFV

VPS

Column (A)

Column (B)

Column (A)

Column (B)

Linearity and range (ng/mL)

120–600

120–600

30–150

30–150

Correlation coefficient (r)

1.0000

1.0000

0.9998

0.9999

Slope

0.029

0.029

0.013

0.038

Intercept

− 0.009

− 0.016

− 0.003

− 0.063

Sy/x

SD of the residuals

0.036

0.023

0.014

0.011

Sa

SD of the intercept

0.034

0.022

0.014

0.010

Sb

SD of the slope

0.0001

0.0001

0.0002

0.0001

SD

0.48

0.28

2.16

0.25

%RSDa

0.483

0.283

2.156

0.252

%Errorb

0.216

0.127

0.965

0.113

LODc

3.94

2.47

3.41

0.90

LOQd

11.94

7.47

10.33

2.74

  1. aPercentage relative standard deviation
  2. bPercentage relative error
  3. cLimit of detection
  4. dLimit of quantitation