Studied drug | Proposed method | Comparison method [11] | |||||
---|---|---|---|---|---|---|---|
Amount taken (ng/mL) | Amount found (ng/mL) | % Found | % Found | ||||
Column (A) | Column (B) | Column (A) | Column (B) | Column (A) | Column (B) | ||
SFV Epclusa® tablet (SFV 400 mg/VPS 100 mg) | 200.0 | 200.0 | 196.900 | 199.520 | 98.45 | 99.76 | 99.98 |
400.0 | 400.0 | 389.760 | 394.920 | 97.44 | 98.73 | 98.93 | |
600.0 | 600.0 | 596.760 | 589.080 | 99.46 | 98.18 | 100.83 | |
Mean | 98.45 | 98.89 | 100.85 | ||||
±SD | 1.01 | 0.80 | 0.95 | ||||
t-test | 1.83 | 1.42 | (2.78)* | ||||
F-test | 1.12 | 1.41 | (19)* | ||||
VPS | 50.0 | 50.0 | 48.810 | 49.955 | 97.62 | 99.91 | 102.45 |
Epclusa® tablet (SFV 400 mg/VPS 100 mg) | 100.0 | 100.0 | 98.000 | 98.040 | 98.00 | 98.04 | 101.78 |
150.0 | 150.0 | 148.665 | 148.185 | 99.11 | 98.79 | 98.91 | |
Mean | 98.24 | 98.91 | 101.05 | ||||
±SD | 0.77 | 0.94 | 1.88 | ||||
t-test | 2.39 | 1.76 | (2.78)* | ||||
F-test | 5.89 | 3.99 | (19.0)* |