|
Studied drug
|
Proposed method
|
Comparison method [11]
|
|---|
|
Amount taken (ng/mL)
|
Amount found (ng/mL)
|
% Found
|
% Found
|
|---|
|
Column (A)
|
Column (B)
|
Column (A)
|
Column (B)
|
Column (A)
|
Column (B)
|
|---|
|
SFV Epclusa® tablet (SFV 400 mg/VPS 100 mg)
|
200.0
|
200.0
|
196.900
|
199.520
|
98.45
|
99.76
|
99.98
|
|
400.0
|
400.0
|
389.760
|
394.920
|
97.44
|
98.73
|
98.93
|
|
600.0
|
600.0
|
596.760
|
589.080
|
99.46
|
98.18
|
100.83
|
|
Mean
| | | | |
98.45
|
98.89
|
100.85
|
|
±SD
| | | | |
1.01
|
0.80
|
0.95
|
|
t-test
| | | | |
1.83
|
1.42
|
(2.78)*
|
|
F-test
| | | | |
1.12
|
1.41
|
(19)*
|
|
VPS
|
50.0
|
50.0
|
48.810
|
49.955
|
97.62
|
99.91
|
102.45
|
|
Epclusa® tablet (SFV 400 mg/VPS 100 mg)
|
100.0
|
100.0
|
98.000
|
98.040
|
98.00
|
98.04
|
101.78
|
|
150.0
|
150.0
|
148.665
|
148.185
|
99.11
|
98.79
|
98.91
|
|
Mean
| | | | |
98.24
|
98.91
|
101.05
|
|
±SD
| | | | |
0.77
|
0.94
|
1.88
|
|
t-test
| | | | |
2.39
|
1.76
|
(2.78)*
|
|
F-test
| | | | |
5.89
|
3.99
|
(19.0)*
|
- Each result is the average of three separate determinations
- * The figures between parentheses are the tabulated t and F values at P = 0.05 [17]
