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Table 12 Assay results for the determination of VPS in its co-formulated tablet with SFV by Method 1

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Studied drug Proposed method Comparison method [11]
Amount taken (ng/mL) Amount found (ng/mL) % Found % Found
Column (A) Column (B) Column (A) Column (B) Column (A) Column (B)
Epclusa® tablet (SFV 400 mg/VPS100 mg) 1.0 2.5 0.982 2.449 98.20 97.99 102.45
3.0 5.0 2.995 4.827 99.84 96.53 101.78
5.0 10.0 5.049 9.782 100.97 97.82 98.91
Mean      99.67 97.45 101.05
 ±SD      1.39 0.80 1.88
t-test      2.74 3.05 (2.78)*
F-test      1.82 5.55 (19.0)*
  1. Each result is the average of three separate determinations
  2. * The figures between parentheses are the tabulated t and F values at P = 0.05 [17]