Table 11 Assay results for the determination of VPS and SFV in their laboratory prepared mixture at their pharmaceutical ratio by Method 2
Studied drug | Proposed method | Comparison method [11] | |||||
|---|---|---|---|---|---|---|---|
Amount taken (ng/mL) | Amount found (ng/mL) | % Found | % Found | ||||
Column (A) | Column (B) | Column (A) | Column (B) | Column (A) | Column (B) | ||
SFV | 120 | 120 | 120.468 | 119.472 | 100.39 | 99.56 | 99.98 |
200 | 200 | 200.140 | 195.560 | 100.07 | 97.78 | 98.93 | |
280 | 280 | 279.720 | 273.000 | 99.90 | 97.50 | 100.83 | |
400 | 400 | 399.520 | 393.600 | 99.88 | 98.40 | ||
600 | 600 | 588.120 | 600.420 | 98.02 | 100.07 | ||
Mean | 99.65 | 98.66 | 100.85 | ||||
±SD | 0.93 | 1.12 | 0.95 | ||||
t-test | 0.38 | 1.61 | (2.45)* | ||||
F-test | 1.04 | 1.38 | (6.94)* | ||||
VPS | 30 | 30 | 30.036 | 29.817 | 100.12 | 99.39 | 101.45 |
50 | 50 | 49.420 | 50.305 | 98.84 | 100.61 | 100.47 | |
70 | 70 | 68.768 | 70.455 | 98.24 | 100.65 | 99.12 | |
100 | 100 | 99.140 | 100.130 | 99.14 | 100.13 | ||
150 | 150 | 149.910 | 149.100 | 99.94 | 99.40 | ||
Mean | 99.26 | 100.04 | 100.35 | ||||
±SD | 0.78 | 0.62 | 1.17 | ||||
t-test | 1.61 | 0.50 | (2.45)* | ||||
F-test | 2.25 | 3.56 | (6.94)* | ||||