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Table 7 Determination of methylphenidate in some pharmaceutical preparations using the membrane sensors

From: New potentiometric sensors for methylphenidate detection based on host–guest interaction

Preparation

Parameter

Sensor 1

Sensor 2

Sensor 3

HPLC

Synthetic form, 5 mg

Measured

4.93

4.92

4.96

4.97

 

R, %

98.6

98.4

99.20

99.4

 

SD

0.09

0.11

0.11

0.13

 

RSD, %

1.83

2.23

2.22

2.61

Ritalin tablet (10 mg)

 

Measured

9.92

9.92

9.8

9.9

 

R, %

98.0

98.5

98

99

 

SD

0.19

0.19

0.22

0.25

 

RSD

1.9

1.95

2.26

2.55

Ttest

0.14

0.14

0.71

 

Ftest

1.73

1.73

1.29

 

Methylphenidate tablet (10 mg)

 

Measured

9.91

9.85

9.81

9.85

 

R, %

99.1

98.5

98.1

98.5

 

SD

0.18

0.19

0.22

0.24

 

RSD, %

1.81

1.93

2.24

2.44

Ttest

0.49

0.5

1.05

 

Ftest

1.19

1.5

1.77

 
  1. R %: recovery %, SD; standard deviation, RSD %: relative standard deviation %