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Table 7 Determination of methylphenidate in some pharmaceutical preparations using the membrane sensors

From: New potentiometric sensors for methylphenidate detection based on host–guest interaction

Preparation Parameter Sensor 1 Sensor 2 Sensor 3 HPLC
Synthetic form, 5 mg Measured 4.93 4.92 4.96 4.97
  R, % 98.6 98.4 99.20 99.4
  SD 0.09 0.11 0.11 0.13
  RSD, % 1.83 2.23 2.22 2.61
Ritalin tablet (10 mg)
  Measured 9.92 9.92 9.8 9.9
  R, % 98.0 98.5 98 99
  SD 0.19 0.19 0.22 0.25
  RSD 1.9 1.95 2.26 2.55
Ttest 0.14 0.14 0.71  
Ftest 1.73 1.73 1.29  
Methylphenidate tablet (10 mg)
  Measured 9.91 9.85 9.81 9.85
  R, % 99.1 98.5 98.1 98.5
  SD 0.18 0.19 0.22 0.24
  RSD, % 1.81 1.93 2.24 2.44
Ttest 0.49 0.5 1.05  
Ftest 1.19 1.5 1.77  
  1. R %: recovery %, SD; standard deviation, RSD %: relative standard deviation %